Now showing items 21-40 of 866

  • ALDH2 mediates 5-nitrofuran activity in multiple species 

    Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie; Temperley, Nicholas; Johnson, Stephen; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan; Melton, David; Smith, Terry K; Tyers, Mike; Westwood, Nicholas James; Patton, Elizabeth (2012-07-27) - Journal article
    Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, ...
  • All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarised cyclohexane 

    Keddie, Neil Steven; Slawin, Alexandra Martha Zoya; Lebl, Tomas; Philp, Douglas; O'Hagan, David (2015-04) - Journal article
    The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, in which all of the fluorines are ‘up’, is prepared in a 12-step protocol. The molecule adopts a classic chair conformation with alternate C–F bonds ...
  • Allosteric modulation of zinc speciation by fatty acids 

    Barnett, James P.; Blindauer, Claudia A.; Kassaar, Omar; Khazaipoul, Siavash; Martin, Esther M.; Sadler, Peter J.; Stewart, Alan J. (2013-12) - Journal article
    Background: Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs. Studies ...
  • alpha-Ketophosphonates as ester surrogates : isothiourea-catalyzed asymmetric diester and lactone synthesis 

    Smith, Siobhan R.; Leckie, Stuart M.; Holmes, Reuben; Douglas, James; Fallan, Charlene; Shapland, Peter; Pryde, David; Slawin, Alexandra M. Z.; Smith, Andrew D. (2014-05-02) - Journal article
    Isothiourea HBTM-2.1 catalyzes the asymmetric Michael addition/lactonization of aryl- and alkenylacetic acids using α-keto-β,γ-unsaturated phosphonates as α,β-unsaturated ester surrogates, giving access to a diverse range ...
  • Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli 

    Lou, Hubing; Chen, Min; Black, Susan S.; Bushell, Simon R.; Ceccarelli, Matteo; Mach, Tivadar; Beis, Konstantinos; Low, Alison S.; Bamford, Victoria A.; Booth, Ian R.; Bayley, Hagan; Naismith, James H. (2011-10-28) - Journal article
    Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges. The permeation of antibiotics through the outer membrane is largely effected by the porin superfamily, changes ...
  • Alternative p-doped hole transport material for low operating voltage and high efficiency organic light-emitting diodes 

    Murawski, Caroline; Fuchs, Cornelius; Hofmann, Simone; Leo, Karl; Gather, Malte C. (2014-09-15) - Journal article
    We investigate the properties of N,N'-[(Diphenyl-N,N'-bis) 9,9,-dimethyl-fluoren-2-yl]-benzidine (BF-DPB) as hole transport material (HTL) in organic light-emitting diodes (OLEDs) and compare BF-DPB to the commonly used ...
  • Amphioxus regeneration : evolutionary and biomedical implications 

    Somorjai, Ildiko Maureen Lara (2017-12-21) - Journal item
    Regeneration is a variable trait in chordates, with some species capable of impressive abilities, and others of only wound healing with scarring. Regenerative capacity has been reported in the literature for 5 species from ...
  • Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks 

    Cormanich, Rodrigo A.; Rittner, Roberto; O'Hagan, David; Buehl, Michael (2014-09-11) - Journal article
    Intramolecular CF···FC interactions in selected organofluorine compounds (all-syn-1,2,3,4- and all-syn-1,2,4,5-tetrafluorocyclohexane, 1,8-difluoronaphthalene, 4,5-difluorophenanthrene, 2,2′,5,5′-tetrafluorobiphenyl) were ...
  • Analysis of influenza A virus NS1 dimer interfaces in solution by pulse EPR distance measurements 

    Kerry, Philip S; Turkington, Hannah L; Ackermann, Katrin; Jameison, Stephen A; Bode, Bela Ernest (2014-08-22) - Journal article
    Pulsed electron-electron double resonance (PELDOR) is an electron paramagnetic resonance (EPR) spectroscopy technique for nanometer distance measurements between paramagnetic centres such as radicals. PELDOR has been ...
  • Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages 

    Sarkies, Peter; Selkirk, Murray E.; Jones, John T.; Blok, Vivian; Boothby, Thomas; Goldstein, Bob; Hanelt, Ben; Ardila-Garcia, Alex; Fast, Naomi M.; Schiffer, Phillip M.; Kraus, Christopher; Taylor, Mark J.; Koutsovoulos, Georgios; Blaxter, Mark L.; Miska, Eric A. (2015-02-10) - Journal article
    Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence. However, the evolutionary relationships ...
  • Anhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processes 

    Robinson, Emily R. T.; Fallan, Charlene; Simal, Carmen; Slawin, Alexandra M. Z.; Smith, Andrew D. (2013) - Journal article
    The asymmetric annulation of a range of alpha,beta-unsaturated acyl ammonium intermediates, formed from isothiourea HBTM 2.1 and anhydrides with either 1,3-dicarbonyls, beta-ketoesters or azaaryl ketones gives either ...
  • Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections 

    Cox-Singh, Janet; Singh, Balbir; Daneshvar, Cyrus; Planche, Timothy; Parker-Williams, John; Krishna, Sanjeev; Cox Singh, Janet (2011-06-08) - Journal article
    Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection. Therefore ...
  • Antibodies for immunolabeling by light and electron microscopy : not for the faint hearted 

    Griffiths, Gareth; Lucocq, John Milton (2014-10) - Journal item
    Reliable antibodies represent crucial tools in the arsenal of the cell biologist and using them to localize antigens for immunocytochemistry is one of their most important applications. However, antibody-antigen interactions ...
  • APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis 

    Odon, Valerie Marie Nathalie; Luke, Garry Alec; Roulston, Claire; De Felipe, Pablo; Ruan, Lin; Escuin, Helena; Brown, Jeremy; Ryan, Martin Denis; Sukhodub, Andriy (2013-08) - Journal article
    2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes ...
  • Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum 

    Guenther, Svenja; Wallace, Lynsey; Patzewitz, Eva-Maria; McMillan, Paul J.; Storm, Janet; Wrenger, Carsten; Bissett, Ryan; Smith, Terry K; Mueller, Sylke (2007-12) - Journal article
    Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways. Biosynthesis ...
  • The application of optical coherence tomography to image subsurface tissue structure of antarctic krill Euphausia Superba 

    Bellini, Nicola; Cox, M.J.; Harper, D.J.; Stott, S.R.; Ashok, P.C.; Dholakia, K.; Kawaguchi, S.; King, R.; Horton, T.; Brown, C.T.A. (2014-10-13) - Journal article
    Many small open ocean animals, such as Antarctic krill, are an important part of marine ecosystems. To discover what will happen to animals such as krill in a changing ocean, experiments are run in aquaria where conditions ...
  • The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain 

    Swiatek, Agnieszka; MacNeill, Stuart Andrew (2010-04-12) - Journal article
    Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) ...
  • Architecture and permeability of post-cytokinesis plasmodesmata lacking cytoplasmic sleeves 

    Nicolas, William J.; Grison, Magali S.; Trépout, Sylvain; Gaston, Amélia; Fouché, Mathieu; Cordelières, Fabrice P.; Oparka, Karl; Tilsner, Jens; Brocard, Lysiane; Bayer, Emmanuelle M. (2017-06-12) - Journal article
    Plasmodesmata are remarkable cellular machines responsible for the controlled exchange of proteins, small RNAs and signalling molecules between cells. They are lined by the plasma membrane (PM), contain a strand of tubular ...
  • Are the sublimation thermodynamics of organic molecules predictable? 

    McDonagh, James L.; Palmer, David S.; van Mourik, Tanja; Mitchell, John B. O. (2016-11-28) - Journal article
    We compare a range of computational methods for the prediction of sublimation thermodynamics (enthalpy, entropy and free energy of sublimation). These include a model from theoretical chemistry that utilizes crystal lattice ...
  • ARID3B: a novel regulator of the Kaposi’s sarcoma-associated herpesvirus lytic cycle 

    Wood, Jennifer; Boyne, James; Paulus, Christina; Jackson, Brian; Nevels, Michael Martin; Whitehouse, Adrian; Hughes, David John (2016-10) - Journal article
    KSHV is the causative agent of commonly fatal malignancies of immuno-compromised individuals, including primary effusion lymphoma (PEL) and Kaposi’s sarcoma (KS). A hallmark of all herpesviruses is their biphasic lifecycle ...