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  • ALDH2 mediates 5-nitrofuran activity in multiple species 

    Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie; Temperley, Nicholas; Johnson, Stephen; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan; Melton, David; Smith, Terry K; Tyers, Mike; Westwood, Nicholas James; Patton, Elizabeth (2012-07-27) - Journal article
    Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, ...