Now showing items 1-2 of 2

  • ALDH2 mediates 5-nitrofuran activity in multiple species 

    Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie; Temperley, Nicholas; Johnson, Stephen; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan; Melton, David; Smith, Terry K; Tyers, Mike; Westwood, Nicholas James; Patton, Elizabeth (2012-07-27) - Journal article
    Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, ...
  • The search for allosteric inhibitors 

    Brear, Paul (University of St Andrews, 2013-06-26) - Thesis
    This thesis describes the development of chemical tools that inhibit the sialidases NanA and NanB from Streptococcus pneumonia. The primary focus was on the discovery of allosteric inhibitors of NanA and NanB, however, ...