Now showing items 1-20 of 375

  • 2-Arylacetic anhydrides as ammonium enolate precursors 

    Morrill, Louis C.; Ledingham, Lyndsay A.; Couturier, Jean-Philippe; Bickel, Jasmine; Harper, Andrew D.; Fallan, Charlene; Smith, Andrew D. (2014-01-28) - Journal article
    Readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (HBTM-2.1)-mediated catalytic asymmetric intermolecular Michael addition-lactonisation processes, giving diverse synthetic ...
  • 2A peptides provide distinct solutions to driving stop-carry on translational recoding 

    Sharma, P; Yan, F; Doronina, V; Escuin-Ordinas, Helena; Ryan, Martin Denis; Brown, Jeremy (2012-04) - Journal article
    Expression of viral proteins frequently includes non-canonical decoding events (‘recoding’) during translation. ‘2A’ oligopeptides drive one such event, termed ‘stop-carry on’ recoding. Nascent 2A peptides interact with ...
  • "2A-like" signal sequences mediating translational recoding : a novel form of dual protein targeting 

    Roulston, Claire; Luke, Garry Alec; de Felipe, Pablo; Ruan, Lin; Cope, Jonathan; Nicholson, John; Sukhodub, Andriy; Tilsner, Jens; Ryan, Martin Denis (2016-06-02) - Journal article
    We report the initial characterisation of an N-terminal oligopeptide ‘2A-like’ sequence that is able to function both as a signal sequence and as a translational recoding element. Due to this translational recoding activity, ...
  • 4273π : bioinformatics education on low cost ARM hardware 

    Barker, Daniel; Ferrier, David Ellard Keith; Holland, Peter W.H.; Mitchell, John B. O.; Plaisier, Heleen; Ritchie, Michael Gordon; Smart, Steven D. (2013-08-12) - Journal article
    Background: Teaching bioinformatics at universities is complicated by typical computer classroom settings. As well as running software locally and online, students should gain experience of systems administration. For a ...
  • Aberrant NF-kappaB expression in autism spectrum condition : a mechanism for neuroinflammation 

    Young, Adam; Campbell, Elaine Catherine; Lynch, Sarah Janice; Suckling, John; Powis, Simon John (2011-05-13) - Journal article
    Autism spectrum condition (ASC) is recognized as having an inflammatory component. Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although ...
  • Accurate extraction of nanometer distances in multimers by pulse EPR 

    Valera, Silvia; Ackermann, Katrin; Pliotas, Christos; Huang, Hexian; Naismith, James Henderson; Bode, Bela Ernest (2016-03-24) - Journal article
    Pulse electron paramagnetic resonance (EPR) is gaining increasing importance in structural biology. The PELDOR (pulsed electron-electron double resonance) method allows extracting distance information on the nanometer ...
  • Acetylation site specificities of lysine deacetylase inhibitors in human cells 

    Schölz, Christian; Weinert, Brian T.; Wagner, Sebastian A.; Beli, Petra; Miyake, Yasuyuki; Qi, Yun; Jensen, Lars J.; Streicher, Werner; McCarthy, Anna Rose; Westwood, Nicholas James; Lain, Sonya; Cox, Jürgen; Matthias, Patrick; Mann, Matthias; Bradner, James E.; Choudhary, Chunaram (2015) - Journal article
    Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely ...
  • Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) 

    Kailainathan, Sumangali; Piers, Thomas M.; Yi, Jee Hyun; Choi, Seongmin; Fahey, Mark S.; Borger, Eva; Gunn-Moore, Francis James; O'Neill, Laurie; Lever, Michael; Whitcomb, Daniel J.; Cho, Kwangwook; Allen, Shelley J. (2016-02) - Journal article
    This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different ...
  • Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis 

    Killip, M. J.; Young, D. F.; Precious, B. L.; Goodbourn, S.; Randall, R. E. (2012-02) - Journal article
    Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating ...
  • Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export 

    Killip, M J; Smith, M; Jackson, D; Randall, R E (2014-04) - Journal article
    We have examined the requirements for virus transcription and replication, and thus the roles of input and progeny genomes, in the generation of IFN-inducing PAMPs by influenza A viruses using inhibitors of these processes. ...
  • The AEROPATH project targeting Pseudomonas aeruginosa : crystallographic studies for assessment of potential targets in early-stage drug discovery 

    Moynie, Lucile; Schnell, Robert; McMahon, Stephen A.; Sandalova, Tatyana; Abdelli Boulkeroua, Wassila; Schmidberger, Jason W.; Alphey, Magnus; Cukier, Cyprian; Duthie, Fraser; Kopec, Jolanta; Liu, Huanting; Jacewicz, Agata; Hunter, William N.; Naismith, James H.; Schneider, Gunter (2013-01) - Journal article
    Bacterial infections are increasingly difficult to treat owing to the spread of antibiotic resistance. A major concern is Gram-negative bacteria, for which the discovery of new antimicrobial drugs has been particularly ...
  • ALDH2 mediates 5-nitrofuran activity in multiple species 

    Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie; Temperley, Nicholas; Johnson, Stephen; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan; Melton, David; Smith, Terry K; Tyers, Mike; Westwood, Nicholas James; Patton, Elizabeth (2012-07-27) - Journal article
    Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, ...
  • All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarised cyclohexane 

    Keddie, Neil Steven; Slawin, Alexandra Martha Zoya; Lebl, Tomas; Philp, Douglas; O'Hagan, David (2015-04) - Journal article
    The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, in which all of the fluorines are ‘up’, is prepared in a 12-step protocol. The molecule adopts a classic chair conformation with alternate C–F bonds ...
  • Allosteric modulation of zinc speciation by fatty acids 

    Barnett, James P.; Blindauer, Claudia A.; Kassaar, Omar; Khazaipoul, Siavash; Martin, Esther M.; Sadler, Peter J.; Stewart, Alan J. (2013-12) - Journal article
    Background: Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs. Studies ...
  • alpha-Ketophosphonates as ester surrogates : isothiourea-catalyzed asymmetric diester and lactone synthesis 

    Smith, Siobhan R.; Leckie, Stuart M.; Holmes, Reuben; Douglas, James; Fallan, Charlene; Shapland, Peter; Pryde, David; Slawin, Alexandra M. Z.; Smith, Andrew D. (2014-05-02) - Journal article
    Isothiourea HBTM-2.1 catalyzes the asymmetric Michael addition/lactonization of aryl- and alkenylacetic acids using α-keto-β,γ-unsaturated phosphonates as α,β-unsaturated ester surrogates, giving access to a diverse range ...
  • Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli 

    Lou, Hubing; Chen, Min; Black, Susan S.; Bushell, Simon R.; Ceccarelli, Matteo; Mach, Tivadar; Beis, Konstantinos; Low, Alison S.; Bamford, Victoria A.; Booth, Ian R.; Bayley, Hagan; Naismith, James H. (2011-10-28) - Journal article
    Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges. The permeation of antibiotics through the outer membrane is largely effected by the porin superfamily, changes ...
  • Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks 

    Cormanich, Rodrigo A.; Rittner, Roberto; O'Hagan, David; Buehl, Michael (2014-09-11) - Journal article
    Intramolecular CF···FC interactions in selected organofluorine compounds (all-syn-1,2,3,4- and all-syn-1,2,4,5-tetrafluorocyclohexane, 1,8-difluoronaphthalene, 4,5-difluorophenanthrene, 2,2′,5,5′-tetrafluorobiphenyl) were ...
  • Analysis of influenza A virus NS1 dimer interfaces in solution by pulse EPR distance measurements 

    Kerry, Philip S; Turkington, Hannah L; Ackermann, Katrin; Jameison, Stephen A; Bode, Bela Ernest (2014-08-22) - Journal article
    Pulsed electron-electron double resonance (PELDOR) is an electron paramagnetic resonance (EPR) spectroscopy technique for nanometer distance measurements between paramagnetic centres such as radicals. PELDOR has been ...
  • Anhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processes 

    Robinson, Emily R. T.; Fallan, Charlene; Simal, Carmen; Slawin, Alexandra M. Z.; Smith, Andrew D. (2013) - Journal article
    The asymmetric annulation of a range of alpha,beta-unsaturated acyl ammonium intermediates, formed from isothiourea HBTM 2.1 and anhydrides with either 1,3-dicarbonyls, beta-ketoesters or azaaryl ketones gives either ...
  • APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis 

    Odon, Valerie Marie Nathalie; Luke, Garry Alec; Roulston, Claire; De Felipe, Pablo; Ruan, Lin; Escuin, Helena; Brown, Jeremy; Ryan, Martin Denis; Sukhodub, Andriy (2013-08) - Journal article
    2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes ...