Now showing items 1-6 of 6

  • Chemical biology studies on 5-nitrofurans and sirtuin inhibitors 

    Zhou, Linna (University of St Andrews, 2012-12) - Thesis
    Part I: Target identification studies are one of the most difficult but rewarding challenges in chemical biology. Part I of this thesis describes target identification studies for 5-nitrofuran containing hits. The ...
  • Design and synthesis of chemical probes for the plekstrin homology domain 

    Elliott, Thomas S. (University of St Andrews, 2010-11-30) - Thesis
    The phosphatidylinositol polyphosphates play a fundamental role in intracellular signalling. Of particular importance is phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P₃], which acts by recruiting effector proteins ...
  • Nitric oxide donors for the treatment of prostate cancer 

    Nortcliffe, Andrew (University of St Andrews, 2013-11-29) - Thesis
    Chapter One provides a general introduction into the biology and chemistry of nitric oxide, with particular focus on the role of nitric oxide in cardiovascular disease, cancer and hypoxia. It also details the types of ...
  • Novel cambinol analogues as potential anticancer agents : an improved understanding of sirtuin isoform selectivity 

    Medda, Federico (University of St Andrews, 2011-06-22) - Thesis
    SIRT1 and SIRT2 are two NAD⁺-dependent deacetylases which negatively modulate the activity of p53, a protein which is involved in cell cycle arrest, senescence and apoptosis following genotoxic stress. Part I of the thesis ...
  • The role of CTCF in the life cycle of human papillomavirus 

    Paris, Christian (University of St Andrews, 2014-06-27) - Thesis
    Papillomaviruses (PV) are epithelium specific DNA viruses that can cause health problems ranging from harmless warts to invasive cancer. Papillomavirus induced tumours most often arise in the cervix where human papillomavirus ...
  • Studies towards the synthesis of the palmerolides 

    Eadie, Scott (University of St Andrews, 2014-06-25) - Thesis
    In 2006, Baker reported the isolation of palmerolide A, a polyketide derived marine macrolide, from the Antarctic tunicate Synoicum adareanum collected in the shallow waters surrounding Anvers Island. This unique macrolide ...