Now showing items 48-67 of 115

  • Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors 

    Kelsey, Thomas W.; McConville, Lauren; Edgar, Angela B.; Ungurianu, Alex I.; Mitchell, Rod T; Anderson, Richard A.; Wallace, W. Hamish B. (2017-07-20) - Journal article
    The accuracy of Follicle Stimulating Hormone as a predictor of azoospermia in adult survivors of childhood cancer is unclear, with conflicting results in the published literature. A systematic review and post hoc analysis ...
  • From normal response to clinical problem : definition and clinical features of fear of cancer recurrence 

    Lebel, Sophie; Ozakinci, Gozde; Humphris, Gerald; Mutsaers, Brittany; Thewes, Belinda; Prins, Judith; Dinkel, Andreas; Butow, Phyllis; Univ Ottawa (2016-08) - Journal item
    Research to date on fear of cancer recurrence (FCR) shows that moderate to high FCR affects 22-87 % of cancer survivors and is associated with higher psychological morbidity (Simard et al J Cancer Surviv 7:300-322, 2013). ...
  • A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk 

    Katz, E.; Dubois-Marshall, S.; Sims, A. H.; Faratian, D.; Li, J.; Smith, E. S.; Quinn, J. A.; Edward, M.; Meehan, R. R.; Evans, E. E.; Langdon, S. P.; Harrison, David James (2010-07-27) - Journal article
    BACKGROUND: C35 is a 12 kDa membrane-anchored protein endogenously over-expressed in many invasive breast cancers. C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. The function of over-expressed C35 ...
  • Genetic and epigenetic analyses of MBD3 in colon and lung cancer 

    Zhu, Y; Harrison, D J; Bader, S A (2004-05-17) - Journal article
    MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our ...
  • Genomic evolution of breast cancer metastasis and relapse 

    Yates, Lucy R.; Knappskog, Stian; Wedge, David; Farmery, James H. R.; Gonzalez, Santiago; Martincorena, Inigo; Alexandrov, Ludmil B.; Van Loo, Peter; Haugland, Hans Kristian; Lilleng, Peer Kaare; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazinska, Patrycja; Bhosle, Shriram G; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; Sawyer, Elinor; Desmedt, Christine; Sotiriou, Christos; Stratton, Michael R.; Sieuwerts, Anieta M.; Lynch, Andy G.; Martens, John W.; Richardson, Andrea L.; Tutt, Andrew; Lønning, Per Eystein; Campbell, Peter J. (2017-08-14) - Journal article
    Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
  • HES5 silencing is an early and recurrent change in prostate tumourigenesis 

    Massie, Charles E.; Spiteri, Inmaculada; Ross-Adams, Helen; Luxton, Hayley; Kay, Jonathan; Whitaker, Hayley C.; Dunning, Mark J.; Lamb, Alastair D.; Ramos-Montoya, Antonio; Brewer, Daniel S.; Cooper, Colin S.; Eeles, Rosalind; Warren, Anne Y.; Tavaré, Simon; Neal, David E.; Lynch, Andy G.; UK Prostate ICGC Group (2015-04-01) - Journal article
    Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...
  • How head and neck consultants manage patients’ emotional distress during cancer follow-up consultations : a multilevel study 

    Zhou, Yuefang; Humphris, Gerald Michael; Ghazali, N; Friderichs, Simon; Grosset, David; Rogers, Simon (2014) - Journal article
    Head and neck cancer (HNC) patients suffer substantial emotional problems. This study aimed to explore how utterance-level variables (source, type and timing of emotional cues) and patient-level variables (e.g. age, gender ...
  • A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells 

    Bader, S A; Walker, M; Harrison, D J (2007-02-26) - Journal article
    MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase ...
  • Human urinary exosomes in bladder cancer patients : properties, concentrations and possible clinical application 

    Riches, Andrew Clive; Powis, Simon John; Mullen, Peter; Harrison, David James; Hacker, Christian; Lucocq, John Milton; Bowness, James Simeon; Chapman, Alex; Cameron, Ruth; McLornan, Liz; Chinn, David John; Leung, Steve (2015-12-11) - Journal article
    OBJECTIVE: High grade bladder cancer is extremely aggressive. Early detection is thus an important challenge. De- velopment of non-invasive diagnostic tools particularly using urine samples could be of importance in the ...
  • Implementation of a human papillomavirus vaccination demonstration project in Malawi : successes and challenges 

    Msyamboza, Kelias Phiri; Mwagomba, Beatrice Matanje; Valle, Moussa; Chiumia, Hastings; Phiri, Twambilire (2017-06-26) - Journal article
    Background:  Cervical cancer is a major public health problem in Malawi. The age-standardized incidence and mortality rates are estimated to be 75.9 and 49.8 per 100,000 population, respectively. The availability of the ...
  • The importance of DNA methylation in prostate cancer development 

    Massie, Charles E.; Mills, Ian G.; Lynch, Andy G. (2017-02) - Journal item
    After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
  • Increased STAT1 signaling in endocrine-resistant breast cancer 

    Huang, Rui; Faratian, Dana; Sims, Andrew H; Wilson, Danielle; Thomas, Jeremy S; Harrison, David J; Langdon, Simon P (2014-04-11) - Journal article
    Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-7/LCC9) variants was performed to identify modifiers of endocrine sensitivity in ...
  • Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells 

    Treanor, Louise; Bellamy, Christopher; Harrison, David J.; Prost, Sandrine (2010-07) - Journal article
    We have previously reported that deletion of the retinoblastoma gene Rb leads to rapid but transient p53 stabilisation. We investigated here the pathways involved. We show that upon Rb-deletion dysregulated E2F activates ...
  • Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells 

    Meehan, James; Ward, Carol; Turnbull, Arran; Bukowski-Wills, Jimi; Finch, Andrew; Jarman, Edward J.; Xintaropoulou, Chrysi; Martinez-Perez, Carlos; Gray, Mark; Pearson, Matthew; Mullen, Peter; Supuran, Claudia T.; Carta, Fabrizio; Harrison, David James; Kunkler, Ian H.; Langdon, Simon (2017) - Journal article
    Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions, ...
  • Insurance implications for individuals with a high risk of breast and ovarian cancer in Europe 

    Morrison, P J; Steel, C M; Vasen, H F A; Eccles, D; Evans, D G R; Moller, P; Hodgson, S; Stoppa-Lyonnet, D; Chang-Claude, J; Caligo, M; Olah, E; Haites, N E; Nevin, N C (1999-10) - Journal article
  • Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study 

    Ross-Adams, H.; Lamb, A. D.; Dunning, M. J.; Halim, S.; Lindberg, J.; Massie, C. M.; Egevad, L. A.; Russell, R.; Ramos-Montoya, A.; Vowler, S. L.; Sharma, N. L.; Kay, J.; Whitaker, H.; Clark, J.; Hurst, R.; Gnanapragasam, V. J.; Shah, N. C.; Warren, A. Y.; Cooper, C. S.; Lynch, A. G.; Stark, R.; Mills, I. G.; Grönberg, H.; Neal, D. E.; Shaw, Greg; Hori, Satoshi; Baridi, Ajoeb; Tran, Maxine; Wadhwa, Karan; Nelson, Adam; Patel, Keval; Thomas, Benjamin; Luxton, Hayley; Gnanpragasam, Vincent; Doble, Andrew; Kastner, Christof; Aho, Tevita; Haynes, Beverley; Partridge, Wendy; Cromwell, Elizabeth; Sangrasi, Asif; Burge, Jo; George, Anne; Stearn, Sara; Corcoran, Marie; Coret, Hansley; Basnett, Gillian; Francis, Indu; Whitington, Thomas; Yuan, Yinyin; Rueda, Oscar; Hadfield, James; Howat, Will; Miller, Jodi; Brewer, Daniel; CamCaP Study Group (2015-09) - Journal article
    Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...
  • Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002 

    Goltsov, Alexey; Tashkandi, Ghassan; Langdon, Simon P.; Harrison, David J.; Bown, James L. (2017-01-15) - Journal article
    The phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin-1 (mTOR1) are two key targets for anti-cancer therapy. Predicting the response of the PI3K/AKT/mTOR1 signalling pathway to targeted therapy is ...
  • Lasing in live mitotic and non-phagocytic cells by efficient delivery of microresonators 

    Schubert, Marcel; Volckaert, Klara; Karl, Markus; Morton, Andrew; Liehm, Philipp; Miles, Gareth Brian; Powis, Simon John; Gather, Malte Christian (2017-01-19) - Journal article
    Reliable methods to individually track large numbers of cells in real time are urgently needed to advance our understanding of important biological processes like cancer metastasis, neuronal network development and wound ...
  • Lifestyle change in the cancer setting using “the teachable moment” : protocol for a proof-of-concept pilot in a Urology Service 

    Lee, Alyssa Sara; Ozakinci, Gozde; Leung, Steve; Humphris, Gerald Michael; Dale, Hannah Louise; Hamlet, Neil (2016-10-21) - Journal article
    Background: Previous research has shown diagnosis or screening for cancer may be a ‘teachable moment’ for prevention through lifestyle change. Previous trials have been successful, but have been delivered via national ...
  • Mathematical modeling of tumor growth and treatment 

    Enderling, Heiko; Chaplain, Mark A. J. (2014) - Journal article
    Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research. An increasing number of ...