Now showing items 38-57 of 114

  • An externally validated age-related model of mean follicle density in the cortex of the human ovary 

    McLaughlin, Marie; Kelsey, Tom; Wallace, W Hamish B; Anderson, Richard A; Telfer, Evelyn E (2015-06) - Journal article
    The population of non-growing follicles present in the ovary is defined as the ovarian reserve. This underpins the reproductive lifespan in women, with its depletion determining age at loss of fertility and the menopause. ...
  • Fertility and parenthood issues in young female cancer patients - a systematic review 

    Sobota, Aleksandra; Ozakinci, Gozde (2014-12) - Journal article
    Purpose: For young women who were diagnosed with cancer prior to having children, reproductive potential might affect quality of life (QoL). This systematic review looks at fertility issues in young female cancer patients, ...
  • FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6 

    Galfre, Elena; Pitt, Samantha Jane; Venturi, Elisa; Sitsapesan, Mano; Zaccai, Nathan R; Tsaneva-Atanasova, Krasimira; O'Neill, Stephen; Sitsapesan, Rebecca (2012-02-21) - Journal article
    Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel ...
  • Fruit, vegetable and dietary carotenoid intakes explain variation in skin-color in young caucasian women : a cross-sectional study 

    Pezdirc, Kristine; Hutchesson, Melinda J.; Whitehead, Ross; Ozakinci, Gozde; Perrett, David; Collins, Clare E. (2015-07-15) - Journal article
    Fruit and vegetables contain carotenoid pigments, which accumulate in human skin, contributing to its yellowness. This effect has a beneficial impact on appearance. The aim was to evaluate associations between diet (fruit, ...
  • General practitioners’ patient-centredness and responses to patients’ emotional cues and concerns : relationships with perceived empathy in areas of high and low socioeconomic deprivation 

    Lundy, Jenna-Marie; Bikker, Annemieke; Higgins, Maria; Watt, Graham C; Little, Paul; Humphris, Gerald Michael; Mercer, Stewart W (2015-03-17) - Journal article
    Background: Physician empathy is important to patients across the socio-economic spectrum. However, whether socioeconomic status (SES) influences how patients’ judge physician empathy is not known. We investigated how ...
  • Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort 

    Becker, Jessica; Czamara, Darina; Scerri, Tom S; Ramus, Franck; Csépe, Valéria; Talcott, Joel B; Stein, John; Morris, Andrew; Ludwig, Kerstin U; Hoffmann, Per; Honbolygó, Ferenc; Tóth, Dénes; Fauchereau, Fabien; Bogliotti, Caroline; Iannuzzi, Stéphanie; Chaix, Yves; Valdois, Sylviane; Billard, Catherine; George, Florence; Soares-Boucaud, Isabelle; Gérard, Christophe-Loïc; van der Mark, Sanne; Schulz, Enrico; Vaessen, Anniek; Maurer, Urs; Lohvansuu, Kaisa; Lyytinen, Heikki; Zucchelli, Marco; Brandeis, Daniel; Blomert, Leo; Leppänen, Paavo Ht; Bruder, Jennifer; Monaco, Anthony P; Müller-Myhsok, Bertram; Kere, Juha; Landerl, Karin; Nöthen, Markus M; Schulte-Körne, Gerd; Paracchini, Silvia; Peyrard-Janvid, Myriam; Schumacher, Johannes (2013-09-11) - Journal article
    Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from ...
  • Genetic and epigenetic analyses of MBD3 in colon and lung cancer 

    Zhu, Y; Harrison, D J; Bader, S A (2004-05-17) - Journal article
    MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our ...
  • Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection 

    Harris, Simon R; Robinson, Carl; Steward, Karen F; Webb, Katy S; Paillot, Romain; Parkhill, Julian; Holden, Matthew T G; Waller, Andrew S (2015-09) - Journal article
    Strangles, the most frequently diagnosed infectious disease of horses worldwide, is caused by Streptococcus equi. Despite its prevalence, the global diversity and mechanisms underlying the evolution of S. equi as a ...
  • Genomic investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen 

    Gillespie, Stephen H; Ling, Clare L; Oravcova, Katarina; Pinheiro, Miguel; Wells, Louise; Bryant, Josephine M; McHugh, Timothy D; Bébéar, Cecile; Webster, David; Harris, Simon R; Seth-Smith, Helena M B; Thomson, Nicholas R (2015-02-01) - Journal article
    Background. Mycoplasma amphoriforme has been associated with infection in patients with Primary Antibody Deficiency (PAD). Little is known about the natural history of infection with this organism and its ability to be ...
  • Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis 

    Weinert, Lucy A; Chaudhuri, Roy R; Wang, Jinhong; Peters, Sarah E; Corander, Jukka; Jombart, Thibaut; Baig, Abiyad; Howell, Kate J; Vehkala, Minna; Välimäki, Niko; Harris, David; Chieu, Tran Thi Bich; Van Vinh Chau, Nguyen; Campbell, James; Schultsz, Constance; Parkhill, Julian; Bentley, Stephen D; Langford, Paul R; Rycroft, Andrew N; Wren, Brendan W; Farrar, Jeremy; Baker, Stephen; Hoa, Ngo Thi; Holden, Matthew T G; Tucker, Alexander W; Maskell, Duncan J; BRaDP1T Consortium (2015-05) - Journal article
    Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates ...
  • Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa 

    Beale, Mathew A; Sabiiti, Wilber; Robertson, Emma J; Fuentes-Cabrejo, Karen M; O'Hanlon, Simon J; Jarvis, Joseph N; Loyse, Angela; Meintjes, Graeme; Harrison, Thomas S; May, Robin C; Fisher, Matthew C; Bicanic, Tihana (2015-06-25) - Journal article
    Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal virulence and patient outcome. We studied a cohort of 230 ...
  • The health and well-being of people with a previous diagnosis of cancer : a record-linkage study in Scotland 

    Evans, J.M.M.; Atherton, I.A.; Dibben, C.; Hubbard, G. (2011-10-30) - Journal article
    Routinely collected health care data (the Scottish Cancer Registry) were record-linked to representative survey data on health and health behaviours (the Government-funded Scottish Health Survey) to compare the health and ...
  • Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence 

    Faratian, Dana; Christiansen, Jason; Gustavson, Mark; Jones, Christine; Scott, Christopher; Um, InHwa; Harrison, David J (2011-10-25) - Journal article
    Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, ...
  • How do medical students respond to emotional cues and concerns expressed by simulated patients during OSCE consultations? - A multilevel study 

    Zhou, Yuefang; Collinson, Alex; Laidlaw, Anita Helen; Humphris, Gerald Michael (2013-10-23) - Journal article
    Objectives: How medical students handle negative emotions expressed by simulated patients during Objective Structured Clinical Examinations (OSCE) has not been fully investigated. We aim to explore (i) whether medical ...
  • A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells 

    Bader, S A; Walker, M; Harrison, D J (2007-02-26) - Journal article
    MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase ...
  • Human IFNAR2 deficiency : lessons for antiviral immunity 

    Duncan, Christopher J. A.; Mohamad, Siti M. B.; Young, Dan Frushard; Skelton, Andrew J.; Leahy, T. Ronan; Munday, Diane Carolyn; Butler, Karina M.; Morfopoulou, Sofia; Brown, Julianne R.; Hubank, Mike; Connell, Jeff; Gavin, Patrick J.; McMahon, Cathy; Dempsey, Eugene; Lynch, Niamh E.; Jacques, Thomas S.; Valappil, Manoj; Cant, Andrew J.; Breuer, Judith; Engelhardt, Karin R.; Randall, Richard Edward; Hambleton, Sophie (2015-09-30) - Journal article
    Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models have been pivotal to understanding the role of IFN-α/β in immunity, although validation of these findings in humans has been limited. ...
  • ICEApl1, an integrative conjugative element related to ICEHin1056, identified in the pig pathogen Actinobacillus pleuropneumoniae 

    Bosse, Janine T.; Li, Yanwen; Crespo, Roberto Fernandez; Chaudhuri, Roy R.; Rogers, Jon; Holden, Matthew T. G.; Maskell, Duncan J.; Tucker, Alexander W.; Wren, Brendan W.; Rycroft, Andrew N.; Langford, Paul R.; BRaDP1T Consortium (2016-06-15) - Journal article
    ICEApl1 was identified in the whole genome sequence of MIDG2331, a tetracycline resistant (MIC = 8 mg/L) serovar 8 clinical isolate of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia. PCR ...
  • Identification and functional characterisation of a novel dopamine beta hydroxylase gene variant associated with ADHD 

    Tong, Janette; McKinley, Leigh-Anne; Cummins, Tarrant; Johnson, Beth; Matthews, Natasha; Vance, Alasdair; Heussler, Helen; Gill, Michael; Kent, Lindsey; Belgrove, Mark; Hawi, Ziarih (2015) - Journal article
    Dysregulation in neurotransmitter signalling has been implicated in the aetiology of ADHD. Polymorphisms of the gene encoding dopamine beta hydroxylase (DBH), a key player in catecholamine signalling, have been shown to ...
  • Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae 

    Bossé, Janine T; Li, Yanwen; Walker, Stephanie; Atherton, Tom; Fernandez Crespo, Roberto; Williamson, Susanna M; Rogers, Jon; Chaudhuri, Roy R; Weinert, Lucy A; Oshota, Olusegun; Holden, Matthew; Maskell, Duncan J; Tucker, Alexander W; Wren, Brendan W; Rycroft, Andrew N; Langford, Paul R; BRaDP1T Consortium (2015-08) - Journal article
    Objectives: The objective of this study was to determine the distribution and genetic basis of trimethoprim resistance in Actinobacillus pleuropneumoniae isolates from pigs in England. Methods: Clinical isolates collected ...
  • Identity and norms : the role of group membership in medical student wellbeing 

    McNeill, Kathleen; Kerr, Annelise; Mavor, Ken (2014) - Journal article
    Medical students experience high levels of mental health problems, which can lead to poor academic performance, substance abuse and burnout. The current paper draw son social psychology to explore the factors underpinning ...