Now showing items 1-20 of 55

  • Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) 

    Kailainathan, Sumangali; Piers, Thomas M.; Yi, Jee Hyun; Choi, Seongmin; Fahey, Mark S.; Borger, Eva; Gunn-Moore, Francis James; O'Neill, Laurie; Lever, Michael; Whitcomb, Daniel J.; Cho, Kwangwook; Allen, Shelley J. (2016-02) - Journal article
    This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different ...
  • Assessment of enzyme inhibition : a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs 

    Ramsay, Rona R.; Tipton, Keith F. (2017-07) - Journal item
    The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several pharmacological purposes. This review ...
  • Autistic Hierarchy of Needs : a guide for working therapeutically with autistic adults 

    Evans-Williams, Claire; Williams, Damien John (2017-08-11) - Conference poster
  • Avoiding medication conflicts for patients with multimorbidities 

    Kovalov, Andrii; Bowles, Juliana Kuster Filipe (Springer, 2016) - Conference item
    Clinical pathways are care plans which detail essential steps in the care of patients with a specific clinical problem, usually a chronic disease. A pathway includes recommendations of medications prescribed at different ...
  • Beyond the numbers : interpreting the 2016 global tuberculosis report to inform policy and practice in the East African Community 

    Sabiiti, Wilber; TWENDE consortium (2017-03-30) - Journal article
    By the year 2000 five East African Community (EAC) member states: Uganda,Kenya, Tanzania, Rwanda and Burundi had adopted the WHO directly observed treatment, short-course (DOTS), a policy meant to speed up the control of ...
  • Biochemical and functional characterization of glycosaminoglycans released from degranulating rat peritoneal mast cells: insights into the physiological role of endogenous heparin 

    Lever, Rebecca; Smailbegovic, Amir; Riffo-Vasquez, Yanira; Gray, Elaine; Hogwood, John; Francis, Stephen M.; Richardson, Neville V.; Page, Clive P.; Mulloy, Barbara (2016-12) - Journal article
    The properties of commercially prepared heparin as an anticoagulant and antithrombotic agent in medicine are better understood than is the physiological role of heparin in its native form, where it is uniquely found in the ...
  • Biosynthesis of magnetic nanoparticles by human mesenchymal stem cells following transfection with the magnetotactic bacterial gene mms6 

    Elfick, Alistair; Rischitor, Grigore; Mouras, Rabah; Azfer, Asim; Lungaro, Lisa; Uhlarz, Marc; Herrmannsdörfer, Thomas; Lucocq, John Milton; Gamal, Wesam; Bagnaninchi, Pierre; Semple, Scott; Salter, Donald M. (2017-01-04) - Journal article
    The use of stem cells to support tissue repair is facilitated by loading of the therapeutic cells with magnetic nanoparticles (MNPs) enabling magnetic tracking and targeting. Current methods for magnetizing cells use ...
  • Ciproxifan, a H3 receptor inverse agonist, reversibly inhibits human monoamine oxidase A and B 

    Hagenow, Stefanie; Stasiak, A.; Ramsay, Rona R.; Stark, Holger (2017-01-13) - Journal article
    Ciproxifan is a well-investigated histamine H3 receptor (H3R) inverse agonist/antagonist, showing an exclusively high species-specific affinity at rodent compared to human H3R. It is well studied as reference compound for ...
  • Codon pair bias and viral vaccine design 

    Luke, Garry Alec; Pathania, Uday Singh; Tulloch, Fiona Ashley; Ryan, Martin Denis (2013-06-29) - Journal article
    Live attenuated vaccines (LAVs) have prevented morbidity and mortality against a number of important viral diseases (such as smallpox and polio) via long-lived humoral and cell-mediated immunity. Unlike inactivated, subunit ...
  • Correct composition of dephased behavioural models 

    Bowles, Juliana Kuster Filipe; Caminati, Marco Bright (Springer, 2017) - Conference item
    Scenarios of execution are commonly used to specify partial behaviour and interactions between different objects and components in a system. To avoid overall inconsistency in specifications, various automated methods have ...
  • Could molecular pathology testing in lung cancer be more cost effective? 

    Walsh, Kathy; Kheng, Yuan; Oniscu, Anca; Harrison, David James; Wallace, William (2016-10) - Journal article
    Aims: EGFR and ALK analysis is routinely undertaken prior to targeted treatment of non-squamous non-small cell lung carcinoma (NSCLC). Increasingly limited resources require molecular pathology services to be cost effective ...
  • Current and future chemotherapy for Chagas disease 

    Gaspar, Luís; Moraes, Carolina B; Freitas-Junior, Lucio H; Ferrari, Stefania; Costantino, Luca; Costi, Maria Paola; Coron, Ross P; Smith, Terence Kenneth; Siqueira-Neto, Jair L; McKerrow, James H; Cordeiro-da-Silva, Anabela (2015-12-01) - Journal article
    American trypanosomiasis, commonly called Chagas disease, is one of the most neglected illnesses in the world and remains one of the most prevalent chronic infectious diseases of Latin America with thousands of new cases ...
  • Data mining approach to estimate the duration of drug therapy from longitudinal electronic medical records 

    Montvida, Olga; Arandelovic, Ognjen; Reiner, Edward; Paul, Sanjoy K. (2017) - Journal article
    Background: Electronic Medical Records (EMRs) from primary/ ambulatory care systems present a new and promising source of information for conducting clinical and translational research. Objectives: To address the methodological ...
  • Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin 

    Kulyk, Olena; Ibbotson, Sally; Moseley, Harry; Valentine, Ronan; Samuel, Ifor David William (2015-12) - Journal article
    Background Topical Photodynamic therapy (PDT) is an effective treatment for superficial non-melanoma skin cancers (NMSC) and dysplasia. During PDT light activates the photosensitiser (PpIX), metabolised from a topical ...
  • Different mutations in a P-type ATPase transporter in Leishmania parasites are associated with cross-resistance to two leading drugs by distinct mechanisms 

    Fernandez-Prada, Christopher; Vincent, Isabel M.; Brotherton, Marie-Christine; Roberts, Mathew; Roy, Gaétan; Rivas, Luis; Leprohon, Philippe; Smith, Terry K.; Ouellette, Marc (2016-12-02) - Journal article
    Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for ...
  • A dose ranging trial to optimize the dose of Rifampin in the treatment of tuberculosis 

    Boeree, Martin J; Diacon, Andreas H; Dawson, Rodney; Narunsky, Kim; du Bois, Jeannine; Venter, Amour; Phillips, Patrick P J; Gillespie, Stephen H; Mc Hugh, Timothy D; Hoelscher, Michael; Heinrich, Norbert; Rehal, Sunita; van Soolingen, Dick; van Ingen, Jakko; Magis-Escurra, Cecile; Burger, David; Plemper van Balen, Georgette; Aarnoutse, Rob E (2015-05-01) - Journal article
    Rationale: Rifampin at a dose of 10 mg/kg was introduced in 1971 based on pharmacokinetic, toxicity and cost considerations. Available data in mice and humans showed that an increase in dose may shorten the duration of ...
  • Drug-disease and drug-drug interactions : systematic examination of recommendations in 12 UK national clinical guidelines 

    Dumbreck, Siobhan; Flynn, Angela; Nairn, Moray; Wilson, Martin; Treweek, Shaun; Mercer, Stewart W; Alderson, Phil; Thompson, Alex; Payne, Katherine; Guthrie, Bruce (2015-03-11) - Journal article
    Objective: To identify the number of drug-disease and drug-drug interactions for exemplar index conditions within National Institute of Health and Care Excellence (NICE) clinical guidelines. Design: Systematic identification, ...
  • The effect of interstitial pressure on therapeutic agent transport : coupling with the tumor blood and lymphatic vascular systems 

    Wu, Min; Frieboes, Hermann B.; Chaplain, Mark A. J.; McDougall, Steven R.; Cristini, Vittorio; Lowengrub, John S. (2014-08-21) - Journal article
    Vascularized tumor growth is characterized by both abnormal interstitial fluid flow and the associated interstitial fluid pressure (IFP). Here, we study the effect that these conditions have on the transport of therapeutic ...
  • Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy : study protocol of a cluster randomized clinical trial (Multi-PAP project) 

    Prados-Torres, Alexandra; del Cura-González, Isabel; Prados-Torres, Daniel; López-Rodríguez, Juan A.; Leiva-Fernández, Francisca; Calderón-Larrañaga, Amaia; López-Verde, Fernando; Gimeno-Feliu, Luis A.; Escortell-Mayor, Esperanza; Pico-Soler, Victoria; Sanz-Cuesta, Teresa; Bujalance-Zafra, M. Josefa; Morey-Montalvo, Mariel; Boxó-Cifuentes, José Ramón; Poblador-Plou, Beatriz; Fernández-Arquero, José Manuel; González-Rubio, Francisca; Ramiro-González, María D.; Coscollar-Santaliestra, Carlos; Martín-Fernández, Jesús; Barnestein-Fonseca, M. Pilar; Valderas-Martínez, José María; Marengoni, Alessandra; Muth, Christiane; Aza-Pascual-Salcedo, Mercedes; Poncel-Falcó, Antonio; Bandrés-Liso, Ana Cristina; Alcaraz-Borrajo, Marta; Ruiz-San-Basilio, José Ma; Mataix-San-Juan, ángel; López-León, Ana Ma; Mateos-Sancho, Carmina; Gimeno-Miguel, Antonio; Hernández-Santiago, Virginia; García-de Blas, Francisca; García-Agua, Nuria; Rodríguez-Barrientos, Ricardo; Vázquez-Alarcón, Rubén; Laguna-Berna, Clara; Márquez-Chamizo, Maria Isabel; Marta-Moreno, Javier; Azcoaga-Lorenzo, Amaya; Abad-Díez, José María; Sánchez-Perruca, Luis; Polentinos-Castro, Elena; Clerencia-Sierra, Mercedes; Ariza-Cardiel, Gloria; González-González, Ana Isabel; Rico-Blázquez, Milagros; Rogero-Blanco, Marisa; Tello-Bernabé, Ma Eugenia; álvarez-Villalba, Mar; Rumayor-Zarzuelo, Mercedes; del Pozo, Carmen Sánchez Celaya; Garrido, José Ignacio Torrente; Aranda, Concepción García; Lafuente, Marina Pinilla; Ma Teresa Delgado Marroquín, Teresa Delgado Marroquín; Molina, Ma José Gracia; Bernal, Javier Cuartero; Martín, Ma Victoria Asín; Domínguez, Susana García; Gorbea, Carlos Bolea; Negre, Antonio Luis Oto; Royo, Eugenio Galve; Taira, Ma Begoña Abadía; Gutiérrez, José Fernando Tomás; Quintana, José Porta; Miguel, Valentina Martín; de las Heras, Esther Mateo; Algora, Carmen Esteban; de Letosa, Ma Teresa Martín Nasarre; Elena Gascón del Prim, Gascón del Prim; Delgado, Noelia Sorinas; Ma Rosario Sanjuan Cortés, Rosario Sanjuan Cortés; Sánchez, Teodoro Corrales; Lucas, Eustaquio Dendarieta; Mínguez Sorio, Ma del Pilar; Marzal, Adolfo Cajal; García, Eduardo Díaz; Álvarez, Juan Carlos García; De Blas González, Francisca García; Pérez, Cristina Guisado; Franco, Alberto López García; Beneitez, Ma Elisa Viñuela; Ana Ballarín González, Ballarín González; Zapata, Ma Isabel Ferrer; Suarez, Esther Gómez; Ortiz, Fernanda Morales; Laguno, Lourdes Carolina Peláez; Gómez, José Luis Quintana; Pascual, Enrique Revilla; López, Francisco Ramón Abellán; Álvaro, Carlos Casado; González, Paulino Cubero; Hamalainen, Santiago Manuel Machín; Fernández, Raquel Mateo; Blanco, Ma Eloisa Rogero; Arce, Cesar Sánchez; Wiesman, Elisa Ceresuela; Galindo, Jorge Olmedo; Marcos, Claudia López; Borda, Soledad Lorenzo; Fernández, Juan Carlos Moreno; Gómez, Belén Muñoz; De Mingo, Enrique Rodríguez; Pascual, Juan Pedro Calvo; Barroso, Margarita Gómez; Serrano, Beatriz López; Peláez, Ma Paloma Morso; González, Fernando Perales; Salvador, Julio Sánchez; Yépez, Jeannet Dolores Sánchez; Alonso, Ana Sosa; Villalba, Ma del Mar Álvarez; Tapia, Purificación Magán; Alcántara, Ma Angelica Fajardo; Alonso, Ma Canto De Hoyos; González, Rosario Iglesias; Antón, Ma Aránzazu Murciano; Pérez, Manuel Antonio Alonso; Lorenzo, Amaya Azcoaga; Medina, Ricardo De Felipe; Laguna, Amaya Nuria López; De Rivera, Eva Martínez Cid; Flores, Iliana Serrano; Rodríguez, Ma Jesús Sousa; Isabel, Ma Soledad Núñez; Sánchez, Jesús Ma Redondo; Llanos, Pedro Sánchez; Campillo, Lourdes Visedo; Izquierdo, Javier Martín; Sainz, Macarena Toro; Jiménez, Ma José Fernández; García, Esperanza Mora; Navarro Jiménez, José Manuel; Gómez, Deborah Gil; Mendoza, Leovigildo Ginel; Luz Pilar de la Mota Ybancos, Pilar de la Mota Ybancos; Genafo, Jaime Sasporte; Rodríguez, Ma José Alcaide; Garach, Elena Barceló; Arteaga, Beatriz Caffarena de; Parrilla, Ma Dolores Gallego; Catalina Sánchez Morales, Sánchez Morales; Chasco, Ma del Mar Loubet; Ríos, Irene Martínez; Delgado, Elena Mateo; Aurioles, Esther Martín; Ruiz, Sylvia Hazañas; Escalante, Nieves Muñoz; Salido, Enrique Leonés; Torres, Ma Antonia Máximo; Rodríguez, Ma Luisa Moya; Gálvez, Encarnación Peláez; Torres, José Manuel Ramírez; Fernández, Cristóbal Trillo; Cañavate, Ma Dolores García Martínez; Mellado, Ma del Mar Gil; Pradilla, Ma Victoria Muñoz; Peña, Ma José Clavijo; Fernández, José Leiva; Romero, Virginia Castillo; Maqueda, Rafael Ángel; Valdés, Gloria Aycart; Santaella, Miguel Domínguez; Vargas, Ana Ma Fernández; García, Irene García; Rodríguez, Antonia González; Mendaño, Ma Carmen Molina; Naranjo, Juana Morales; Torres, Catalina Moreno; Guerra, Francisco Serrano; Multi-PAP Group (2017-04-27) - Journal article
    Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of ...