Now showing items 1-20 of 98

  • Aberrant NF-kappaB expression in autism spectrum condition : a mechanism for neuroinflammation 

    Young, Adam; Campbell, Elaine Catherine; Lynch, Sarah Janice; Suckling, John; Powis, Simon John (2011-05-13) - Journal article
    Autism spectrum condition (ASC) is recognized as having an inflammatory component. Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although ...
  • Abnormal center-periphery gradient in spatial attention in simultanagnosia 

    Balslev, Daniela; Odoj, Bartholomaeus; Rennig, Johannes; Karnath, Hans-Otto (2014-06-04) - Journal article
    Patients suffering from simultanagnosia cannot perceive more than one object at a time. The underlying mechanism is incompletely understood. One hypothesis is that simultanagnosia reflects "tunnel vision," a constricted ...
  • Active drumming experience increases infants' sensitivity to audiovisual synchrony during observed drumming actions 

    Gerson, Sarah; Schiavio, Andrea; Timmers, Renee; Hunnius, Sabine (2015-06-25) - Journal article
    In the current study, we examined the role of active experience on sensitivity to multisensory synchrony in six-month-old infants in a musical context. In the first of two experiments, we trained infants to produce a novel ...
  • Adapting to time : duration channels do not mediate human time perception 

    Curran, WIlliam; Benton, Christopher; Harris, Julie; Hibbard, Paul Barry; Beattie, L (2016-03) - Journal article
    Accurately encoding the duration and temporal order of events is essential for survival and important to everyday activities, from holding conversations to driving in fast-flowing traffic. Although there is a growing body ...
  • Adding a psychological dimension to mass gatherings medicine 

    Hopkins, Nick; Reicher, Stephen (2016-06) - Journal article
    Objectives. Mass gatherings pose distinctive challenges for medicine. One neglected aspect of this is that the behaviour of people participating in such events is different from the behaviour they exhibit in their everyday ...
  • Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice 

    Witts, Emily Charlotte; Nascimento, Filipe; Miles, Gareth Brian (2015-10) - Journal article
    Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS, including motor control ...
  • Age-dependent cognitive inflexibility in great apes 

    Marin Manrique, Hector; Call, Josep (2015-04) - Journal article
    The ability to suppress and/or change behaviour on the basis of negative feedback, often conceptualized as cognitive flexibility, has rarely been investigated in nonhuman great apes across a broad age range. In this study, ...
  • Allelic variation in CRHR1 predisposes to panic disorder : evidence for biased fear processing 

    Weber, Heike; Richter, Jan; Straube, Benjamin; Lueken, Ulrike; Domschke, Katharina; Schartner, Christoph; Klauke, Benedikt; Baumann, Christian; Pané-Farré, Christiane; Jacob, Christian P.; Scholz, Claus-Jürgen; Zwanger, Peter; Lang, Thomas; Fehm, Lydia; Jansen, Andreas; Konrad, Carsten; Fydrich, Thomas; Wittman, Andre; Pfleiderer, Bettina; Ströhle, Andreas; Gerlach, Alexander L.; Alpers, Georg W.; Arolt, Volker; Pauli, Paul; Wittchen, Hans-Ulrich; Kent, Lindsey; Hamm, Alfons; Kircher, Tilo; Deckert, Jürgen; Reif, Andreas (2015) - Journal article
    Corticotropin releasing hormone (CRH) is a major regulator of the hypothalamicpituitary-adrenal (HPA) axis. Binding to its receptor CRHR1 triggers the downstream release of cortisol, a hormone needed for regulation of ...
  • An application of formal concept analysis to neural decoding 

    Endres, D M; Foldiak, Peter; Priss, U (CEUR-WS, 2008) - Conference item
    This paper proposes a novel application of Formal Concept Analysis (FCA) to neural decoding: the semantic relationships between the neural representations of large sets of stimuli are explored using concept lattices. In ...
  • Arrays of microscopic organic LEDs for high resolution optogenetics 

    Steude, Anja; Witts, Emily Charlotte; Miles, Gareth Brian; Gather, Malte Christian (2016-05-06) - Journal article
    Optogenetics is a paradigm changing new method to study and manipulate the behavior of cells with light. Following major advances of the used genetic constructs over the last decade, the light sources required for optogenetic ...
  • ASS234, as a new Multi-Target Directed propargylamine for Alzheimer’s disease therapy 

    Marco-Contelles, José; Unzeta, Mercedes; Esteban, Gerard; Ramsay, Rona; Romero, Alejandro; Martínez-Murillo, Ricardo; Carreiras, Maria C.; Ismaili, Lhassane; Bolea, Irene (2016-06-28) - Journal item
    The complex nature of Alzheimer’s disease (AD) has prompted the design of Multi-Target-Directed Ligands (MTDL) able to bind to diverse biochemical targets involved in the progress and development of the disease. In this ...
  • Association of British Neurologists : revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis 

    Scolding, Neil; Barnes, David; Cader, Sarah; Chataway, Jeremy; Chaudhuri, Abhijit; Coles, Alasdair; Giovannoni, Gavin; Miller, David; Rashid, Waqar; Schmierer, Klaus; Shehu, Abdullah; Silber, Eli; Young, Carolyn; Zajicek, John (2015-08) - Journal article
    In June 1999, the Association of British Neurologists (ABN) first published guidelines for the use of the licensed multiple sclerosis (MS) disease-modifying treatments (at that time β-interferon and glatiramer acetate). ...
  • Axonal localization of integrins in the CNS is neuronal type and age dependent 

    Andrews, Melissa Renee; Soleman, Sara; Cheah, Menghon; Tumbarello, David; Mason, Matthew; Moloney, Elizabeth; Verhaagen, Joost; Bensadoun, Jean-Charles; Schneider, Bernard; Aebischer, Patrick; Fawcett, James (2016-07) - Journal article
    The regenerative ability of CNS axons decreases with age however this ability remains largely intact in PNS axons throughout adulthood. These differences are likely to correspond with age-related silencing of proteins ...
  • The biological bases of conformity 

    Morgan, T.J.H.; Laland, K.N. (2012-06-14) - Journal article
    Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favor adaptive learning strategies that facilitate effective copying ...
  • Brain swelling and death in children with cerebral malaria 

    Seydel, Karl B; Kampondeni, Samuel D; Valim, Clarissa; Potchen, Michael J; Milner, Danny A; Muwalo, Francis W; Birbeck, Gretchen L; Bradley, William G; Fox, Lindsay L; Glover, Simon J; Hammond, Colleen A; Heyderman, Robert S; Chilingulo, Cowles A; Molyneux, Malcolm E; Taylor, Terrie E (2015-03-19) - Journal article
    Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological ...
  • Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns 

    Charlesworth, Paul; Morton, Andrew; Eglen, Stephen J; Komiyama, Noboru H; Grant, Seth G N (2015) - Journal article
    The function of the nervous system depends on the integrity of synapses and the patterning of electrical activity in brain circuits. The rapid advances in genome sequencing reveal a large number of mutations disrupting ...
  • The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial : a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis 

    Ball, Susan; Vickery, Jane; Hobart, Jeremy; Wright, Dave; Green, Colin; Shearer, James; Nunn, Andrew; Cano, Mayam Gomez; MacManus, David; Miller, David; Mallik, Shahrukh; Zajicek, John (2015-02) - Journal article
    BACKGROUND: The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial aimed to determine whether or not oral Δ9-tetrahydrocannabinol (Δ9-THC) slowed the course of progressive multiple sclerosis (MS); ...
  • A cluster of cholinergic premotor interneurons modulates mouse locomotor activity 

    Zagoraiou, L; Akay, T; Martin, J F; Brownstone, R M; Jessell, T M; Miles, Gareth Brian (2009-12-10) - Journal article
    Mammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive prominent “C bouton” cholinergic inputs ...
  • A common neural system mediating two different forms of social judgement 

    Hall, J.; Whalley, H. C.; McKirdy, J. W.; Sprengelmeyer, R.; Santos, I. M.; Donaldson, D. I.; McGonigle, D. J.; Young, A. W.; McIntosh, A. M.; Johnstone, E. C.; Lawrie, S. M. (2010-07) - Journal article
    Background. A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function. Previous studies have shown that individuals with ...
  • A compact light-sheet microscope for the study of the mammalian central nervous system 

    Yang, Zhengyi; Haslehurst, Peter; Scott, Suzanne; Emptage, Nigel; Dholakia, Kishan (2016-05-24) - Journal article
    Investigation of the transient processes integral to neuronal function demands rapid and high-resolution imaging techniques over a large field of view, which cannot be achieved with conventional scanning microscopes. Here ...