Now showing items 1-18 of 18

  • Adenovirus-mediated Cre deletion of floxed sequences in primary mouse cells is an efficient alternative for studies of gene deletion 

    Prost, Sandrine; Sheahan, Sheahan; Rannie, Dominic; Harrison, David (2001-08-15) - Journal article
    This study evaluates the utility of Cre-expressing adenovirus for deletion of floxed genes in primary cells using primary murine hepatocytes. Adenovirus infection was very efficient, even at very low MOI (>95% infection ...
  • Antitumour activity of the novel flavonoid oncamex in preclinical breast cancer models 

    Martínez-Pérez, Carlos; Ward, Carol; Turnbull, Arran K; Mullen, Peter; Cook, Graham; Meehan, James; Jarman, Edward J; Thomson, Patrick I T; Campbell, Colin J; McPhail, Donald; Harrison, David James; Langdon, Simon P (2016-03-31) - Journal article
    Background: The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved cell uptake and ...
  • ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major 

    Williams, Roderick A. M.; Smith, Terry K.; Cull, Benjamin; Mottram, Jeremy C.; Coombs, Graham H. (2012-05-17) - Journal article
    Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required ...
  • Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections 

    Daneshvar, Cyrus; Davis, Timothy M. E.; Cox Singh, Janet; Rafa'ee, Mohammad Z.; Zakaria, Siti K.; Divis, Paul C. S.; Singh, Balbir (2010-08-19) - Journal article
    Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man ...
  • Cytoadherence and virulence - the case of Plasmodium knowlesi malaria 

    Fatih, Farrah A.; Siner, Angela; Ahmed, Atique; Woon, Lu Chan; Craig, Alister G.; Singh, Balbir; Krishna, Sanjeev; Cox Singh, Janet (2012-02-03) - Journal article
    Background: Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria. Cytoadherence is mediated by specific binding of ...
  • The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes : the MRC-ILA Heart Study 

    Morton, Allison C; Rothman, Alexander M K; Greenwood, John P; Gunn, Julian; Chase, Alex; Clarke, Bernard; Hall, Alistair S; Fox, Keith; Foley, Claire; Banya, Winston; Wang, Duolao; Flather, Marcus D; Crossman, David C (2015-02-07) - Journal article
    Aims: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers ...
  • Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus 

    Overton, Ian M.; Graham, Shirley; Gould, Katherine A.; Hinds, Jason; Botting, Catherine H.; Shirran, Sally; Barton, Geoffrey J.; Coote, Peter J. (2011-05-12) - Journal article
    Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source ...
  • Human tissue in systems medicine 

    Caie, Peter; Schuur, Klaas; Oniscu, Anca; Mullen, Peter; Reynolds, Paul Andrew; Harrison, David James (2013-12) - Journal item
    Histopathology, the examination of an architecturally artefactual, two dimensional, static image remains a potent tool allowing diagnosis and empirical expectation of prognosis. Considerable optimism exists that the advent ...
  • Human urinary exosomes in bladder cancer patients : properties, concentrations and possible clinical application 

    Riches, Andrew Clive; Powis, Simon John; Mullen, Peter; Harrison, David James; Hacker, Christian; Lucocq, John Milton; Bowness, James Simeon; Chapman, Alex; Cameron, Ruth; McLornan, Liz; Chinn, David John; Leung, Steve (2015-12-11) - Journal article
    OBJECTIVE: High grade bladder cancer is extremely aggressive. Early detection is thus an important challenge. De- velopment of non-invasive diagnostic tools particularly using urine samples could be of importance in the ...
  • Knowlesi malaria in Vietnam 

    Cox Singh, Janet (2009-11-26) - Journal article
    The simian malaria parasite Plasmodium knowlesi is transmitted in the forests of Southeast Asia. Symptomatic zoonotic knowlesi malaria in humans is widespread in the region and is associated with a history of spending time ...
  • Micro-geographic risk factors for malarial infection 

    Myers, Ward P.; Myers, Andrea P.; Cox Singh, Janet; Lau, Hui C.; Mokuai, Benny; Malley, Richard (2009-02-13) - Journal article
    Background: Knowledge of geography is integral to the study of insect-borne infectious disease such as malaria. This study was designed to evaluate whether geographic parameters are associated with malarial infection in ...
  • Morphological features and differential counts of Plasmodium knowlesi parasites in naturally acquired human infections 

    Lee, Kim-Sung; Cox Singh, Janet; Singh, Balbir (2009-04-21) - Journal article
    Background: Human infections with Plasmodium knowlesi, a simian malaria parasite, are more common than previously thought. They have been detected by molecular detection methods in various countries in Southeast Asia, where ...
  • One For All? Hitting multiple Alzheimer’s Disease targets with one drug 

    Hughes, Rebecca E.; Nikolic, Katarina; Ramsay, Rona Ruth (2016-04-25) - Journal item
    Alzheimer’s Disease is a complex and multifactorial disease for which the mechanism is still not fully understood. As new insights into disease progression are discovered, new drugs must be designed to target those aspects ...
  • Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth 

    Arastoo, Mohammed; Hacker, Christian; Popovics, Petra; Lucocq, John Milton; Stewart, Alan J. (2016-02) - Journal article
    Neurite growth is central to the formation and differentiation of functional neurons and recently, an essential role for phospholipase C-η2 (PLCη2) in neuritogenesis was revealed. Here we investigate the function of PLCη2 ...
  • Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression 

    Brookes, K; Hawi, Ziarah; Park, J; Scott, S; Gill, M; Kent, Lindsey (2010-12) - Journal article
    Previous studies in animals and humans have implicated the X-chromosome STS gene in the etiology of attentional difficulties and attention deficit hyperactivity disorder (ADHD). This family based association study has fine ...
  • Provision of breast cancer risk information to women at the lower end of the familial risk spectrum 

    Ozakinci, Gozde; Humphris, Gerald; Steel, Michael (2007-12) - Journal article
    Background. Breast cancer family clinics provide risk information as one of their key functions. Many referrals to these clinics are 'low-risk' women. Objective: It was the aim of this study to report on the generic risk ...
  • Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen streptococcus suis 

    Holden, Matthew T. G.; Hauser, Heidi; Sanders, Mandy; Ngo, Thi Hoa; Cherevach, Inna; Cronin, Ann; Goodhead, Ian; Mungall, Karen; Quail, Michael A.; Price, Claire; Rabbinowitsch, Ester; Sharp, Sarah; Croucher, Nicholas J.; Chieu, Tran Bich; Mai, Nguyen Thi Hoang; Diep, To Song; Chinh, Nguyen Tran; Kehoe, Michael; Leigh, James A.; Ward, Philip N.; Dowson, Christopher G.; Whatmore, Adrian M.; Chanter, Neil; Iversen, Pernille; Gottschalk, Marcelo; Slater, Josh D.; Smith, Hilde E.; Spratt, Brian G.; Xu, Jianguo; Ye, Changyun; Bentley, Stephen; Barrell, Barclay G.; Schultsz, Constance; Maskell, Duncan J.; Parkhill, Julian (2009-07-15) - Journal article
    Background: Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major ...
  • Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings : a case report 

    Cox Singh, Janet; Hiu, Jessie; Lucas, Sebastian B.; Divis, Paul C.; Zulkarnaen, Mohammad; Chandran, Patricia; Wong, Kum T.; Adem, Patricia; Zaki, Sherif R.; Singh, Balbir; Krishna, Sanjeev (2010-01-11) - Journal article
    Background: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here. Case ...