Now showing items 1-20 of 71

  • Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis 

    Killip, M. J.; Young, D. F.; Precious, B. L.; Goodbourn, S.; Randall, R. E. (2012-02) - Journal article
    Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating ...
  • Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export 

    Killip, M J; Smith, M; Jackson, D; Randall, R E (2014-04) - Journal article
    We have examined the requirements for virus transcription and replication, and thus the roles of input and progeny genomes, in the generation of IFN-inducing PAMPs by influenza A viruses using inhibitors of these processes. ...
  • ARID3B: a novel regulator of the Kaposi’s sarcoma-associated herpesvirus lytic cycle 

    Wood, Jennifer; Boyne, James; Paulus, Christina; Jackson, Brian; Nevels, Michael Martin; Whitehouse, Adrian; Hughes, David John (2016-10) - Journal article
    KSHV is the causative agent of commonly fatal malignancies of immuno-compromised individuals, including primary effusion lymphoma (PEL) and Kaposi’s sarcoma (KS). A hallmark of all herpesviruses is their biphasic lifecycle ...
  • Association of human papillomavirus 16 E2 with Rad50-interacting protein 1 enhances viral DNA replication 

    Campos-León, Karen; Wijendra, Kalpanee; Siddiqa, Abida; Pentland, Ieisha; Feeney, Katherine M.; Knapman, Alison; Davies, Rachel; Androphy, Elliot J.; Parish, Joanna L. (2017-03) - Journal article
    Rad50-interacting protein 1 (Rint1) associates with the DNA damage response protein Rad50 during the transition from the S phase to the G2/M phase and functions in radiation-induced G2 checkpoint control. It has also been ...
  • Bluetongue virus NS4 protein is an interferon antagonist and a determinant of virus virulence 

    Ratinier, Maxime; Shaw, Andrew E.; Barry, Gerald; Gu, Quan; Di Gialleonardo, Luigina; Janowicz, Anna; Varela, Mariana; Randall, Richard E.; Caporale, Marco; Palmarini, Massimo (2016-06-01) - Journal article
    Bluetongue virus (BTV) is the causative agent of bluetongue, a major infectious disease of ruminants with serious consequences to both animal health and the economy. The clinical outcome of BTV infection is highly variable ...
  • Bunyaviruses and the type I interferon system 

    Elliott, Richard Michael; Weber, F (2009-11-23) - Journal article
    The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop ...
  • Cetacean morbillivirus : current knowledge and future directions 

    Van Bressem, M.-F.; Duignan, P.J.; Banyard, A.; Barbieri, M.; Colegrove, K.M.; de Guise, S.; di Guardo, G.; Dobson, A.; Domingo, M.; Fauquier, D.; Fernandez, A.; Goldstein, T.; Grenfell, B.; Groch, K.R.; Gulland, F.; Jensen, B.A.; Jepson, P.D.; Hall, A.; Kuiken, T.; Mazzariol, S.; Morris, S.E.; Nielsen, O.; Raga, J.A.; Rowles, T.K.; Saliki, J.; Sierra, E.; Stephens, N.; Stone, B.; Tomo, I.; Wang, J.; Waltzek, T.; Wellehan, J.F.X. (2014-12-22) - Journal article
    We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has ...
  • Conservation of a crystallographic interface suggests a role for beta-sheet augmentation in influenza virus NS1 multifunctionality 

    Kerry, Philip Stephen; Long, E; Taylor, Margaret Alexandra; Russell, Rupert James Martin (2011-08-01) - Journal article
    The effector domain (ED) of the influenza virus virulence factor NS1 is capable of interaction with a variety of cellular and viral targets, although regulation of these events is poorly understood. Introduction of a W187A ...
  • CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry 

    Fros, Jelke J.; Dietrich, Isabelle; Alshaikhahmed, Kinda; Passchier, Tim C.; Evans, David John; Simmonds, Peter (2017-09-29) - Journal article
    Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through ...
  • The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster 

    Zhang, Jing; Kasciukovic, Taciana; White, Malcolm F. (2012-10-08) - Journal article
    The Cas4 protein is one of the core CRISPR-associated (Cas) proteins implicated in the prokaryotic CRISPR system for antiviral defence. Cas4 is thought to play a role in the capture of new viral DNA sequences for incorporation ...
  • Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain 

    Potter, Jane A.; Randall, Richard Edward; Taylor, Garry L. (2008-02-28) - Journal article
    Background: IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral infection. In the initial stage of the intracellular antiviral response two RNA ...
  • Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism 

    Dong, Haohao; Li, Ping; Boettcher, Bettina; Elliott, Richard M.; Dong, Changjiang (2013-08) - Journal article
    Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe. Like all orthobunyaviruses, SBV contains a tripartite ...
  • Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA 

    Hao, Li; Holden, Matthew T. G.; Wang, Xin; Andrew, Lubomira; Wellnitz, Sabine; Hu, Fang; Whaley, Melissa; Sammons, Scott; Knipe, Kristen; Frace, Mike; McNamara, Lucy A; Liberator, Paul; Anderson, Annaliesa S (2018-04-04) - Journal article
    Neisseria meningitidis serogroup B (MnB) was responsible for two independent meningococcal disease outbreaks at universities in the USA during 2013. The first at University A in New Jersey included nine confirmed cases ...
  • DNA‐Interacting characteristics of the archaeal Rudiviral protein SIRV2_Gp1 

    Peeters, Eveline; Boon, Maarten; Rollie, Clare Jane Catherine; Willaert, Ronnie G.; Voet, Marleen; White, Malcolm Frederick; Prangishvili, David; Lavigne, Rob; Quax, Tessa E. F. (2017-07) - Journal article
    Whereas the infection cycles of many bacterial and eukaryotic viruses have been characterized in detail, those of archaeal viruses remain largely unexplored. Recently, studies on a few model archaeal viruses such as SIRV2 ...
  • Efficient detection of long dsRNA in vitro and in vivo using the dsRNA binding domain from FHV B2 protein 

    Monsion, Baptiste; Incarbone, Marco; Hleibieh, Kamal; Poignavent, Vianney; Ghannam, Ahmed; Dunoyer, Patrice; Daeffler, Laurent; Tilsner, Jens; Ritzenthaler, Christophe (2018-02-01) - Journal article
    Double-stranded RNA (dsRNA) plays essential functions in many biological processes, including the activation of innate immune responses and RNA interference. dsRNA also represents the genetic entity of some viruses and is ...
  • Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis 

    Sabiiti, Wilber; Robertson, Emma; Beale, Mathew A; Johnston, Simon A; Brouwer, Annemarie E; Loyse, Angela; Jarvis, Joseph N; Gilbert, Andrew S; Fisher, Matthew C; Harrison, Thomas S; May, Robin C; Bicanic, Tihana (2014-05-01) - Journal article
    Background. Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor fungal clearance during treatment are recognized adverse ...
  • Establishment of a reverse genetics system for Schmallenberg virus, a newly emerged orthobunyavirus in Europe 

    Elliott, Richard M.; Blakqori, Gjon; van Knippenberg, Ingeborg C.; Koudriakova, Elina; Li, Ping; McLees, Angela; Shi, Xiaohong; Szemiel, Agnieszka M. (2013-04) - Journal article
    Schmallenberg virus (SBV) is a newly emerged orthobunyavirus that has caused widespread disease in cattle, sheep and goats in Europe. Like other orthobunyaviruses, SBV is characterized by a tripartite negative-sense RNA ...
  • Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi 

    Foster, Deshka; Cox Singh, Janet; Mohamad, Dayang S. A.; Krishna, Sanjeev; Chin, Pek P.; Singh, Balbir (2014-02-18) - Journal article
    Background: Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, infects humans and can cause fatal malaria. It is difficult to diagnose by microscopy because of morphological similarity to Plasmodium ...
  • Evidence of improving antiretroviral therapy treatment delays : an analysis of eight years of programmatic outcomes in Blantyre, Malawi 

    Sloan, Derek J.; Van Oosterhout, Joep J.; Malisita, Ken; Phiri, Eddie M.; Lalloo, David G.; O'Hare, Bernadette; MacPherson, Peter (2013-05-21) - Journal article
    AbstractBackground: Impressive achievements have been made towards achieving universal coverage of antiretroviral therapy (ART) in sub-Saharan Africa. However, the effects of rapid ART scale-up on delays between HIV ...
  • Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system 

    Hsu, Li-Yang; Harris, Simon R; Chlebowicz, Monika A; Lindsay, Jodi A; Koh, Tse-Hsien; Krishnan, Prabha; Tan, Thean-Yen; Hon, Pei-Yun; Grubb, Warren B; Bentley, Stephen D; Parkhill, Julian; Peacock, Sharon J; Holden, Matthew Tg (2015-04-23) - Journal article
    Background In the past decade, several countries have seen gradual replacement of endemic multi-resistant healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) with clones that are more susceptible to ...