Now showing items 21-32 of 32

    • Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis 

      Sloan, Derek James; Mwandumba, Henry C.; Garton, Natalie J.; Khoo, Saye H.; Butterworth, Anthony E.; Allain, Theresa J.; Heyderman, Robert S.; Corbett, Elizabeth L.; Barer, Mike R.; Davies, Geraint R. (2015-07-01) - Journal article
      Background. Antibiotic-tolerant bacterial persistence prevents treatment shortening in drug-susceptible tuberculosis, and accumulation of intracellular lipid bodies has been proposed to identify a persister phenotype of ...
    • Phenotypic changes on Mycobacterium tuberculosis-specific CD4 T cells as surrogate markers for tuberculosis treatment efficacy 

      Ahmed, Mohamed I. M.; Ntinginya, Nyanda E.; Kibiki, Gibson; Mtafya, Bariki A; Semvua, Hadija; Mpagama, Stellah; Mtabho, Charles; Saathoff, Elmar; Held, Kathrin; Loose, Rebecca; Kroidl, Inge; Chachage, Mkunde; Both, Ulrich von; Haule, Antelmo; Mekota, Anna-Maria; Boeree, Martin J.; Gillespie, Stephen H.; Hoelscher, Michael; Heinrich, Norbert; Geldmacher, Christof; Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) (2018-09-28) - Journal article
      Background: The analysis of phenotypic characteristics on Mycobacterium tuberculosis (MTB)-specific T cells is a promising approach for the diagnosis of active tuberculosis (aTB) and for monitoring treatment success. We ...
    • Regional susceptibility to TNF-alpha induction of murine brain inflammation via classical IKK/NF-kappa B signalling 

      Young, Adam M. H.; Campbell, Elaine C.; Lynch, Sarah; Dunn, Malcolm H.; Powis, Simon J.; Suckling, John (2012-06-11) - Journal article
      It is becoming clear that inflammation plays a significant role in a number of neurological and psychiatric conditions. Post mortem brain samples in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, ...
    • Short-sighted virus evolution and a germline hypothesis for chronic viral infections 

      Lythgoe, Katrina A.; Gardner, Andy; Pybus, Oliver G.; Grove, Joe (2017-05) - Journal article
      With extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to changing environments. This ability is generally beneficial to viruses as it allows them to evade host immune responses, ...
    • Single-cell studies of IFN-β promoter activation by wildtype and NS1-defective influenza A viruses 

      Killip, Marian Jane; Jackson, David; Pérez - Cidoncha, Maite; Fofor, Ervin; Randall, Richard Edward (2017-03) - Journal article
      Deletion or truncation of NS1, the principal interferon (IFN) antagonist of influenza viruses, leads to increased IFN induction during influenza virus infection. We have studied activation of the IFN induction cascade by ...
    • A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses 

      Le Gallou, Simon; Zhou, Zhicheng; Thai, Lan-Huong; Fritzen, Remi; de Los Aires, Alba Verge; Mégret, Jérôme; Yu, Philipp; Kitamura, Daisuke; Bille, Emmanuelle; Tros, Fabiola; Nassif, Xavier; Charbit, Alain; Weller, Sandra; Weill, Jean-Claude; Reynaud, Claude-Agnès (2018-06-29) - Journal article
      To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse ...
    • T cell immunity to the alkyl hydroperoxide reductase of Burkholderia pseudomallei : a correlate of disease outcome in acute melioidosis 

      Reynolds, Catherine; Goudet, Amélie; Jenjaroen, Kemajittra; Sumonwiriya, Manutsanun; Rinchai, Darawan; Musson, Julie; Overbeek, Saskia; Makinde, Julia; Quigley, Kathryn; Manji, Jiten; Spink, Natasha; Yos, Pagnarith; Wuthiekanun, Vanaporn; Bancroft, Gregory; Robinson, John; Lertmemongkolchai, Ganjana; Dunachie, Susanna; Maillere, Bernard; Holden, Matthew; Altmann, Daniel; Boyton, Rosemary (2015-05-15) - Journal article
      There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and ...
    • Unusual tissue distribution of carcinin, an antibacterial crustin, in the crab, Carcinus maenas, reveals its multi-functionality 

      Suleiman, Suzanne; Smith, Valerie J.; Dyrynda, Elisabeth A. (2017-11) - Journal article
      Crustins are whey acidic four-disulphide core (WFDSC) domain-containing proteins in decapods that are widely regarded as antimicrobial agents that contribute to host defence. Whilst there have been many analyses of crustin ...
    • Vaccinia virus immunomodulator A46 : a lipid and protein-binding scaffold for sequestering host TIR-domain proteins 

      Fedosyuk, Sofiya; Bezerra, Gustavo Arruda; Radakovics, Katharina; Smith, Terry K.; Sammito, Massimo; Bobik, Nina; Round, Adam; Ten Eyck, Lynn F.; Djinović-Carugo, Kristina; Usón, Isabel; Skern, Tim (2016-12-14) - Journal article
      Vaccinia virus interferes with early events of the activation pathway of the transcriptional factor NF-kB by binding to numerous host TIR-domain containing adaptor proteins. We have previously determined the X-ray structure ...
    • Whole-genome sequencing of nine esophageal adenocarcinoma cell lines 

      Contino, Gianmarco; Eldridge, Matthew D.; Secrier, Maria; Bower, Lawrence; Elliott, Rachael Fels; Weaver, Jamie; Lynch, Andy G.; Edwards, Paul A.W.; Fitzgerald, Rebecca C. (2016-06-10) - Journal article
      Esophageal adenocarcinoma (EAC) is highly mutated and molecularly heterogeneous. The number of cell lines available for study is limited and their genome has been only partially characterized. The availability of an accurate ...
    • Why do adaptive immune responses cross-react? 

      Fairlie-Clarke, KJ; Shuker, David Michael; Graham, AL (2009-02) - Journal article
      Antigen specificity of adaptive immune responses is often in the host's best interests, but with important and as yet unpredictable exceptions. For example, antibodies that bind to multiple flaviviral or malarial species ...
    • Within host RNA virus persistence : mechanisms and consequences 

      Randall, Richard E.; Griffin, Diane E. (2017-04) - Journal item
      In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA ...