Now showing items 691-710 of 1092

  • A perspective on multi-target drug discovery and design for complex diseases 

    Ramsay, Rona R.; Popovic-Nikolicb, Marija R.; Nikolic, Katarina; Uliassi, Elisa; Bolognesi, Maria Laura (2018-01-17) - Journal item
    Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential ...
  • PFClust : a novel parameter free clustering algorithm 

    Mavridis, Lazaros; Nath, Neetika; Mitchell, John B. O. (2013-07-03) - Journal article
    Background: We present the algorithm PFClust (Parameter Free Clustering), which is able automatically to cluster data and identify a suitable number of clusters to group them into without requiring any parameters to be ...
  • pH controlled assembly of a self-complementary halogen-bonded dimer 

    Maugeri, Leonardo; Jamieson, Ellen; Cordes, David Bradford; Slawin, Alexandra Martha Zoya; Philp, Douglas (2017-02-01) - Journal article
    Phenols and their corresponding phenoxide anions can form halogen bonds with neutral iodotriazoles. The strength of these interactions depends critically on the protonation state of the oxygen atom – the interaction of the ...
  • Phase composition and disorder in La2(Sn,Ti)2O7 ceramics : new insights from NMR crystallography 

    Fernandes, Arantxa; McKay, David; Sneddon, Scott; Dawson, Daniel McLean; Lawson, Sebastian; Veazey, Richard; Whittle, Karl; Ashbrook, Sharon Elizabeth Marie (2016-09-15) - Journal article
    An NMR crystallographic approach, involving the combination of 119Sn NMR spectroscopy, XRD and DFT calculations, is demonstrated for the characterisation of La2Sn2–xTixO7 ceramics. A phase change from pyrochlore (La2Sn2O7) ...
  • Phase transformation of Mg-calcite to aragonite in active-forming hot spring travertines 

    Greer, Heather Frances; Zhou, Wuzong; Guo, Li (2015) - Journal article
    A travertine specimen collected from the western part of Yunnan Province of China was subjected to microstructural analysis by powder X-ray diffraction, scanning electron microscopy, high resolution transmission electron ...
  • Phase transition behavior of the layered perovskite CsBi0.6La0.4Nb2O7 : a hybrid improper ferroelectric 

    Dixon, Charlotte A. L.; McNulty, Jason A.; Knight, Kevin S.; Gibbs, Alexandra S.; Lightfoot, Philip (2017-05-13) - Journal article
    The phase behavior of the layered perovskite CsBi0.6La0.4Nb2O7, of the Dion-Jacobson family, has been studied by high-resolution powder neutron diffraction between temperatures 25 < T < 850 °C. At ambient temperature this ...
  • Phenyl(2,4,5-triphenylcyclopenta-1,4-dien-1-yl)methanone 

    Cordes, David B.; Hua, Guoxiong; Slawin, Alexandra M. Z.; Woollins, J. Derek (2011-07) - Journal article
    The title compound, C30H22O, does not form face-to-face pi-pi interactions despite the presence of four phenyl rings within the compound. Instead weak C-H center dot center dot center dot pi interactions occur between ...
  • Phosphite ligands in Ru-based olefin metathesis catalysts 

    Bantreil, Xavier; Cazin, Catherine S.J. (2015-07) - Journal article
    In this short review, we focus on the synthesis and applications of new phosphite-bearing ruthenium complexes in olefin metathesis. These complexes were designed to take advantage of a known synergistic effect between ...
  • Phosphorescent platinum(II) complexes bearing pentafluorosulfanyl substituted cyclometalating ligands 

    Henwood, Adam Francis; Webster, James; Cordes, David Bradford; Slawin, Alexandra Martha Zoya; Jacquemin, Denis; Zysman-Colman, Eli (2017-05-12) - Journal article
    The first examples of phosphorescent platinum(II) complexes bearing pentafluorosulfanyl (-SF5) substituted cyclometalating ligands (C^N) are reported. These complexes are of the form [Pt(C^N)(pivacac)], where pivacac is ...
  • Phosphorus-sulfur heterocycles incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O scaffold : one-pot synthesis and crystal structure study 

    Hua, Guoxiong; Davidson, Kate; Cordes, David B.; Du, Junyi; Slawin, Alexandra M. Z.; Woollins, J. Derek (2017-10-10) - Journal article
    A new one-pot preparative route was developed to synthesize novel organophosphorus sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4-diferrocenyl 1,3,2,4-diathiadiphosphetane 2,4-disulfide ...
  • Photochemically induced dynamic nuclear polarization observed by solid-state NMR in a uniformly 13C-isotope labeled photosynthetic reaction center 

    Paul, Shubhajit; Bode, Bela Ernest; Matysik, Jörg; Alia, Alia (2015-10-29) - Journal article
    A sample of solubilized and quinone-depleted reaction centers (RC) from the purple bacterium Rhodobacter (R.) sphaeroides wild-type (WT) has been prepared entirely 13C and 15N isotope labelled at all positions of the protein ...
  • Photoinduced electron transfer in supramolecular ruthenium-porphyrin assemblies 

    Rota Martir, Diego; Averardi, Mattia; Escudero, Daniel; Jacquemin, Denis; Zysman-Colman, Eli (2017-02-21) - Journal article
    We present dynamic supramolecular systems composed of a Ru(II) complex of the form of [Ru(dtBubpy)2(qpy)][PF6]2 (where dtBubpy is 4,4′-di-tert-butyl-2,2′-dipyridyl and qpy is 4,4':2',2'':4'',4'''-quaterpyridine) and zinc ...
  • Photophysical and structural characterisation of in situ formed quantum dots 

    Bansal, A. K.; Antolini, F.; Sajjad, M. T.; Stroea, L.; Mazzaro, R.; Ramkumar, S. G.; Kass, K. -J.; Allard, S.; Scherf, U.; Samuel, I. D. W. (2014-04-11) - Journal article
    Conjugated polymer-semiconductor quantum dot (QD) composites are attracting increasing attention due to the complementary properties of the two classes of materials. We report a convenient method for in situ formation of ...
  • Physical properties of the WASP-67 planetary system from multi-colour photometry 

    Mancini, L.; Southworth, J.; Ciceri, S.; Calchi Novati, S.; Dominik, M.; Henning, Th.; Jørgensen, U. G.; Korhonen, H.; Nikolov, N.; Alsubai, K. A.; Bozza, V.; Bramich, D. M.; D'Ago, G.; Figuera Jaimes, R.; Galianni, P.; Gu, S.-H.; Harpsøe, K.; Hinse, T. C.; Hundertmark, M.; Juncher, D.; Kains, N.; Popovas, A.; Rabus, M.; Rahvar, S.; Skottfelt, J.; Snodgrass, C.; Street, R.; Surdej, J.; Tsapras, Y.; Vilela, C.; Wang, X.-B.; Wertz, O. (2014-08) - Journal article
    Context. The extrasolar planet WASP-67 b is the first hot Jupiter definitively known to undergo only partial eclipses. The lack of the second and third contact points in this planetary system makes it difficult to obtain ...
  • Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system 

    Mielenz, Dirk; Gunn-Moore, Francis James (2016-08-15) - Journal item
    Synaptic dysfunction and dysregulation of Ca2+ are linked to neurodegenerative processes and behavioural disorders. Our understanding of the causes and factors involved in behavioural disorders and neurodegeneration, ...
  • Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule 

    Yang, Jianhong; Wang, Yuxi; Wang, Taijing; Jiang, Jian; Botting, Catherine Helen; Liu, Huanting; Chen, Qiang; Yang, Jingliang; Naismith, James Henderson; Zhu, Xiaofeng; Chen, Lijuan (2016-06-30) - Journal article
    Molecules which alter the normal dynamics of microtubule assembly and disassembly 
include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin 
and structural biology has explained the basis ...
  • A planar dianionic ditelluride and a cyclic tritelluride supported by P2N2 rings 

    Nordheider, Andreas; Chivers, Tristram; Thirumoorthi, Ramalingam; Arachchige, Kasun S. Athukorala; Slawin, Alexandra M. Z.; Woollins, J. Derek; Vargas-Baca, Ignacio (2013) - Journal article
    Oxidation of alkali metal derivatives of [Te((BuN)-Bu-t) P(mu-(NBu)-Bu-t)(2)P((NBu)-Bu-t)Te](2-)with I-2 produces the intermediate ditelluride dianion [Te((BuN)-Bu-t)P(mu-(NBu)-Bu-t)(2)P((NBu)-Bu-t)Te](2)(2-) with a planar ...
  • Planar P6E6 (E = Se, S) macrocycles incorporating P2N2 scaffolds 

    Nordheider, Andreas; Chivers, Tristram; Thirumoorthi, Ramalingam; Vargas-Baca, Ignacio; Woollins, J. Derek (2012-05) - Journal article
    Oxidation of alkali metal derivatives of the dianions [E((BuN)-Bu-t)P(mu-(NBu)-Bu-t)(2)P((NBu)-Bu-t)E](2-) (E = S, Se) with I-2 produces 15-membered macrocycles in which a planar P6E6 motif is stabilised by perpendicular ...
  • Platinum bis(phosphine) complexes of 1,8-naphthosultam 

    Diamond, Louise M.; Knight, Fergus R.; Randall, Rebecca A. M.; Fuller, Amy L.; Slawin, Alexandra M. Z.; Woollins, J. Derek (2014-11-01) - Journal article
    A series of bis(phosphine) platinum complexes 1-4 and 6-8 that bear the 1,8-naphthosultam ligand (L) have been synthesised. The nitrogen atom in L was deprotonated with sodium tert-butoxide to form the sodium salt. ...
  • Platinum bisphosphine complexes of 1,8-naphthosultone 

    Diamond, Louise; Knight, Fergus Ross; Cordes, David B.; Fuller, Amy; Slawin, Alexandra Martha Zoya; Woollins, J Derek (2014-10-15) - Journal article
    A series of three platinum (II) bisphosphine complexes 1-3 [Pt(1-(SO2),8-(O)-nap)(PR3)2] (where R3 = Ph3, Ph2Me, Me2Ph) have been prepared by metathesis from cis-[Pt(PR3)2Cl2)] and the dilithium salt of 1,8-naphthosultone. ...