A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis
Abstract
A titania photoredox catalysis protocol was developed for the homocoupling of C-centered radicals derived from carboxylic acids. Intermolecular reactions were generally efficient and selective, furnishing the desired dimers in good yields under mild neutral conditions. Selective cross-coupling with two acids proved unsuccessful. An intramolecular adaptation enabled macrocycles to be prepared, albeit in modest yields.
Citation
Manley , D W & Walton , J C 2014 , ' A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis ' , Organic Letters , vol. 16 , no. 20 , pp. 5394-5397 . https://doi.org/10.1021/ol502625w
Publication
Organic Letters
Status
Peer reviewed
ISSN
1523-7060Type
Journal article
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