Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange
Abstract
Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching—and subtly tuning—NP properties such as solvophilicity.
Citation
della Sala , F & Kay , E R 2015 , ' Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange ' , Angewandte Chemie International Edition , vol. 54 , no. 14 , pp. 4187–4191 . https://doi.org/10.1002/anie.201409602
Publication
Angewandte Chemie International Edition
Status
Peer reviewed
ISSN
1433-7851Type
Journal article
Rights
© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Description
This work was supported by the EPSRC (EP/K016342/1 and DTG), the University of St Andrews, and by a Royal Society of Edinburgh/Scottish Government Fellowship (E.R.K.).Collections
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