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Please use this identifier to cite or link to this item: http://hdl.handle.net/10023/3247
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Title: Why do adaptive immune responses cross-react?
Authors: Fairlie-Clarke, KJ
Shuker, David Michael
Graham, AL
Keywords: Heterologous immunity
Information processing
Optimal discrimination
Optimal immunology
Sex-ration adjustment
T-cell repertoire
Plasmodium-falciparum
Immunological memory
Protective immunity
Schistosoma-mansoni
Antibody-responses
Influenza-virus
Apis-mellifera
Infection
QR180 Immunology
Issue Date: Feb-2009
Citation: Fairlie-Clarke , K J , Shuker , D M & Graham , A L 2009 , ' Why do adaptive immune responses cross-react? ' Evolutionary Applications , vol 2 , no. 1 , pp. 122-131 .
Abstract: Antigen specificity of adaptive immune responses is often in the host's best interests, but with important and as yet unpredictable exceptions. For example, antibodies that bind to multiple flaviviral or malarial species can provide hosts with simultaneous protection against many parasite genotypes. Vaccinology often aims to harness such imprecision, because cross-reactive antibodies might provide broad-spectrum protection in the face of antigenic variation by parasites. However, the causes of cross-reactivity among immune responses are not always known, and here, we explore potential proximate and evolutionary explanations for cross-reactivity. We particularly consider whether cross-reactivity is the result of constraints on the ability of the immune system to process information about the world of antigens, or whether an intermediate level of cross-reactivity may instead represent an evolutionary optimum. We conclude with a series of open questions for future interdisciplinary research, including the suggestion that the evolutionary ecology of information processing might benefit from close examination of immunological data.
Version: Publisher PDF
Status: Peer reviewed
URI: http://hdl.handle.net/10023/3247
DOI: http://dx.doi.org/10.1111/j.1752-4571.2008.00052.x
ISSN: 1752-4571
Type: Journal article
Rights: © 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Appears in Collections:Scottish Oceans Institute Research
Biology Research
University of St Andrews Research



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