Research@StAndrews
 
The University of St Andrews

Research@StAndrews:FullText >
University of St Andrews Research >
University of St Andrews Research >
University of St Andrews Research >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10023/3243
This item has been viewed 18 times in the last year. View Statistics

Files in This Item:

File Description SizeFormat
Jaeger_et_al_Neuropsychologia_2012_Developmental.pdf904.6 kBAdobe PDFView/Open
Title: Prefrontal cortex contributions to controlled memory judgment : fMRI evidence from adolescents and young adults
Authors: Jaeger, Antonio
Selmeczy, Diana
O'Connor, Akira Robert
Diaz, Michael
Dobbins, Ian
Keywords: Adolescence
Cueing
Development
Memory
Recognition
BF Psychology
Issue Date: Dec-2012
Citation: Jaeger , A , Selmeczy , D , O'Connor , A R , Diaz , M & Dobbins , I 2012 , ' Prefrontal cortex contributions to controlled memory judgment : fMRI evidence from adolescents and young adults ' Neuropsychologia , vol 50 , no. 14 , pp. 3745-3756 .
Abstract: Cortical regions supporting cognitive control and memory judgment are structurally immature in adolescents. Here we studied adolescents (13-15 y.o.) and young adults (20-22 y.o.) using a recognition memory paradigm that modulates cognitive control demands through cues that probabilistically forecast memory probe status. Behaviorally, adolescence was associated with quicker responding in the presence of invalid cues compared to young adulthood. FMRI data demonstrated that while both groups increasingly activated posterior dorsolateral prefrontal (dlPFC), midline, and lateral parietal regions for invalidly compared to validly cued trials, this differential invalid cueing response ended sooner in adolescents, consistent with their generally quicker responding on cued trials. Critically, dlPFC also demonstrated reversed brain-behavior associations across the groups. Increased mean dlPFC activation during invalid cueing was linked to improved performance in young adults, whereas increases within adolescents were linked to impaired performance. Resting state connectivity analysis revealed greater connectivity between dlPFC and episodic retrieval linked regions in young adults relative to adolescents. These data demonstrate that the functional interpretation of dlPFC activation hinges on its physical maturation and suggest that the pattern of behavioral and neural response in adolescents reflects different functional integration of cognitive control and memory systems.
Version: Postprint
Status: Peer reviewed
URI: http://hdl.handle.net/10023/3243
DOI: http://dx.doi.org/10.1016/j.neuropsychologia.2012.10.022
ISSN: 0028-3932
Type: Journal article
Rights: This is an author version of this work. The published version (c) 2012 Elsevier Ltd is available from http://www.sciencedirect.com
Appears in Collections:Psychology & Neuroscience Research
University of St Andrews Research



This item is protected by original copyright

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

DSpace Software Copyright © 2002-2012  Duraspace - Feedback
For help contact: Digital-Repository@st-andrews.ac.uk | Copyright for this page belongs to St Andrews University Library | Terms and Conditions (Cookies)