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Title: Association between common variation at the FTO locus and changes in Body Mass Index from infancy to late childhood : the complex nature of genetic association through growth and development
Authors: Sovio, Ulla
Mook-Kanamori, Dennis O.
Warrington, Nicole M.
Lawrence, Robert
Briollais, Laurent
Palmer, Colin N.A.
Cecil, Joanne Elizabeth
Sandling, Johanna
Syvänen, Ann-Christine
Kaakinen, Marika
Beilin, Lawrie
Millwood, Iona
Bennett, Amanda
Laitinen, Jaana
Pouta, Anneli
Molitor, John
Davey Smith, George
Ben-Shlomo, Yoav
Jaddoe, Vincent
Palmer, Lyle
Pennell, Craig
Cole, Tim
McCarthy, Mark
Järvelin, Marjo-Riitta
Timpson, Nicholas
Keywords: QH426 Genetics
Issue Date: 2011
Citation: Sovio , U , Mook-Kanamori , D O , Warrington , N M , Lawrence , R , Briollais , L , Palmer , C N A , Cecil , J E , Sandling , J , Syvänen , A-C , Kaakinen , M , Beilin , L , Millwood , I , Bennett , A , Laitinen , J , Pouta , A , Molitor , J , Davey Smith , G , Ben-Shlomo , Y , Jaddoe , V , Palmer , L , Pennell , C , Cole , T , McCarthy , M , Järvelin , M-R & Timpson , N 2011 , ' Association between common variation at the FTO locus and changes in Body Mass Index from infancy to late childhood : the complex nature of genetic association through growth and development ' PLoS Genetics , vol 7 , no. 2 , e1001307 .
Abstract: An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We metaanalyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ancestry. We found a positive association between additional minor (A) alleles and BMI from 5.5 years onwards, but an inverse association below age 2.5 years. Modelling median BMI curves for each genotype using the LMS method, we found that carriers of minor alleles showed lower BMI in infancy, earlier adiposity rebound (AR), and higher BMI later in childhood. Differences by allele were consistent with two independent processes: earlier AR equivalent to accelerating developmental age by 2.37% (95% CI 1.87, 2.87, p = 10220) per A allele and a positive age by genotype interaction such that BMI increased faster with age (p = 10223). We also fitted a linear mixed effects model to relate genotype to the BMI curve inflection points adiposity peak (AP) in infancy and AR. Carriage of two minor alleles at rs9939609 was associated with lower BMI at AP (20.40% (95% CI: 20.74, 20.06), p = 0.02), higher BMI at AR (0.93% (95% CI: 0.22, 1.64), p = 0.01), and earlier AR (24.72% (25.81, 23.63), p = 10217), supporting cross-sectional results. Overall, we confirm the expected association between variation at rs9939609 and BMI in childhood, but only after an inverse association between the same variant and BMI in infancy. Patterns are consistent with a shift on the developmental scale, which is reflected in association with the timing of AR rather than just a global increase in BMI. Results provide important information about longitudinal gene effects and about the role of FTO in adiposity. The associated shifts in developmental timing have clinical importance with respect to known relationships between AR and both later-life BMI and metabolic disease risk.
Version: Publisher PDF
Status: Peer reviewed
URI: http://hdl.handle.net/10023/2322
DOI: http://dx.doi.org/10.1371/journal.pgen.1001307
ISSN: 1553-7390
Type: Journal article
Rights: © 2011 Sovio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:University of St Andrews Research
Medicine Research



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