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Please use this identifier to cite or link to this item: http://hdl.handle.net/10023/1439
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Title: Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat
Authors: Adamson, Catherine S
Sakalian, M
Salzwedel, K
Freed, E.O.
Keywords: QR355 Virology
Issue Date: Apr-2010
Citation: Adamson , C S , Sakalian , M , Salzwedel , K & Freed , E O 2010 , ' Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat ' Retrovirology , vol 7 , 36 .
Abstract: Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A patient’s failure to respond correlated with baseline polymorphisms at SP1 residues 6-8. Results: In this study, we demonstrate that varying levels of BVM resistance are associated with point mutations at these residues. BVM susceptibility was maintained by SP1-Q6A, -Q6H and -T8A mutations. However, an SP1-V7A mutation conferred high-level BVM resistance and SP1-V7M and T8Δ mutations conferred intermediate levels of BVM resistance. Conclusions: Future exploitation of the CA-SP1 cleavage site as an antiretroviral drug target will need to overcome the baseline variability in the SP1 region of Gag.
Version: Publisher PDF
Status: Peer reviewed
URI: http://hdl.handle.net/10023/1439
DOI: http://dx.doi.org/10.1186/1742-4690-7-36
ISSN: 1742-4690
Type: Journal article
Rights: © 2010 Adamson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:University of St Andrews Research
Medicine Research
Biomedical Sciences Research Complex (BSRC) Research



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