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Title: The regulation of type I interferon production by paramyxoviruses
Authors: Goodbourn, S
Randall, Richard Edward
Keywords: Respiratory syncytial virus
Viral-rna synthesis
Nonstructural c protein
Induced antiviral state
Cysteine-rich domain
Double-stranded-rna
Measles-virus
V-Protein
Sendai-virus
RIG-I
QR355 Virology
Issue Date: Sep-2009
Citation: Goodbourn , S & Randall , R E 2009 , ' The regulation of type I interferon production by paramyxoviruses ' Journal of Interferon and Cytokine Research , vol 29 , no. 9 , pp. 539 - 547 .
Abstract: Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha. However, in the last few years it has become clear that viruses in general mount a major challenge to the IFN system, and paramyxoviruses are no exception. Indeed, most paramyxoviruses encode mechanisms to inhibit both the production of, and response to, type I IFN. Here we review our knowledge of the type I IFN-inducing signals (by so-called pathogen-associated molecular patterns, or PAMPs) produced during paramyxovirus infections, and discuss how paramyxoviruses limit the production of PAMPs and inhibit the cellular responses to PAMPs by interfering with the activities of the pattern recognition receptors (PRRs), mda-5, and RIG-I, as well as downstream components in the type I IFN induction cascades.
Version: Publisher PDF
Description: Research supported by The Wellcome Trust (087751/A/08/Z)
Status: Peer reviewed
URI: http://hdl.handle.net/10023/1194
DOI: http://dx.doi.org/10.1089/jir.2009.0071
ISSN: 1079-9907
Type: Journal article
Rights: This is a copy of an article accepted in the Journal of Interferon and Cytokine Research © 2009 [copyright Mary Ann Liebert, Inc.]; Journal of Interferon and Cytokine Research is available online at: http://www.liebertonline.com.
Appears in Collections:University of St Andrews Research
Biology Research
Biomedical Sciences Research Complex (BSRC) Research



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