The Cajal body and the nucleolus : “in a relationship” or “it's complicated”?
Abstract
From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the two structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.
Citation
Trinkle-Mulcahy , L & Sleeman , J E 2017 , ' The Cajal body and the nucleolus : “in a relationship” or “it's complicated”? ' , RNA Biology , vol. 14 , no. 6 , pp. 739-751 . https://doi.org/10.1080/15476286.2016.1236169
Publication
RNA Biology
Status
Peer reviewed
ISSN
1547-6286Type
Journal item
Rights
© 2016, Taylor & Francis. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.tandfonline.com / https://dx.doi.org/10.1080/15476286.2016.1236169
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