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| Title: | The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain |
| Authors: | Swiatek, Agnieszka
MacNeill, Stuart Andrew |
| Keywords: | QH301 Biology |
| Issue Date: | 12-Apr-2010 |
| Citation: | Swiatek , A & MacNeill , S A 2010 , ' The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain ' Biology Direct , vol 5 , no. 1 , pp. 17 . |
| Abstract: | Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) of archaeal primase and the B-domains of the archaeo-eukaryotic GINS proteins in the form of a conserved structural domain comprising a three-stranded antiparallel beta-sheet adjacent to an alpha-helix and a two-stranded beta-sheet or hairpin. The presence of a shared domain in archaeal PriS and GINS proteins, the genes for which are often found adjacent on the chromosome, suggests simple mechanisms for the evolution of these proteins. |
| Version: | Publisher PDF |
| Status: | Peer reviewed |
| URI: | http://hdl.handle.net/10023/1047
http://www.biology-direct.com/content/5/1/17 |
| DOI: | http://dx.doi.org/10.1186/1745-6150-5-17 |
| ISSN: | 1745-6150 |
| Type: | Journal article |
| Rights: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Appears in Collections: | University of St Andrews Research
Biology Research
Biomedical Sciences Research Complex (BSRC) Research
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