One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase
Abstract
We report, for the first time, the use of tryptophan synthase in the generation of L- dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.
Citation
Corr , M J , Smith , D R M & Goss , R J M 2016 , ' One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase ' , Tetrahedron , vol. 72 , no. 46 , pp. 7306-7310 . https://doi.org/10.1016/j.tet.2016.02.016
Publication
Tetrahedron
Status
Peer reviewed
ISSN
0040-4020Type
Journal article
Description
The authors thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779, and the University of St Andrews for a studentship (to D. R. M. Smith).Collections
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